Jeptha W. Davenport

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The plasma membrane of Neurospora crassa contains an electrogenic H+-ATPase (EC, for which we have isolated and sequenced both genomic and cDNA clones. The ATPase gene is interrupted by four small introns (58-124 base pairs). It encodes a protein of 920 amino acids (Mr, 99,886) possessing as many as eight transmembrane segments. The Neurospora(More)
Five groups of female rats which were exposed to thiouracil for varying periods around the time of birth were compared with a 6th group of untreated controls in motivational, metabolic, and hormonal test situations during adolescence and adulthood. The thiouracil-treated rats displayed reduced fearfulness in lever-touching and lever-pressing tasks in(More)
Rats reared on diets containing tricyanoaminopropene, the antithyroid compound that stimulates RNA synthesis, showed a deficit in performance on automated closed-field maze tests many weeks after discontinuation of the drug. The rats were also tested while still receiving the drug, and performance deficits were indicated in tests of Y-maze reversal and(More)
Behavioral deficits in adult rats exposed perinatally to thiouracil were substantially reduced or elimated by a 5-week period of "superenriched" postweaning rearing conditions before testing. This treatment resulted in remediation of hypothyroid rats' deficits in maze learning, maze retention, and resistance to extinction of bar-pressing; the facilitative(More)
In leaves and intact chloroplasts, oxidation and reduction have been shown previously to regulate the ATPase activity of thylakoids. Illumination of spinach chloroplast thylakoids in the presence of dithiothreitol, which activates the ability of thylakoids to catalyze sustained ATP hydrolysis in the dark, causes increased incorporation of N-ethylmaleimide(More)
Disease modifying therapies (DMTs) reduce the frequency of relapses and accumulation of disability in multiple sclerosis (MS). Long-term persistence with treatment is important to optimize treatment benefit. This long-term, cohort study was conducted at the Calgary MS Clinic. All consenting adults with relapsing-remitting MS who started either glatiramer(More)