• Publications
  • Influence
Facile preparation of a hybrid nanoprobe for triple-modality optical/PET/MR imaging.
89Zr-labeled dextran nanoparticles allow in vivo macrophage imaging.
A new macrophage specific positron emission tomography imaging agent, labeled with zirconium-89 ((89)Zr), that was based on a cross-linked, short chain dextran nanoparticle (13 nm) that was found to be located primarily in tissue resident macrophages rather than other white blood cells. Expand
Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques
Rationale: Myeloid cell content in atherosclerotic plaques associates with rupture and thrombosis. Thus, imaging of lesional monocytes and macrophages could serve as a biomarker of diseaseExpand
Phage display selection of peptides that home to atherosclerotic plaques: IL-4 receptor as a candidate target in atherosclerosis
Results show that the CRKRLDRNC peptide homes to atherosclerotic plaques through binding to IL‐4R as its target and may be a useful tool for selective drug delivery and molecular imaging of atherosclerosis. Expand
Combined Cerenkov luminescence and nuclear imaging of radioiodine in the thyroid gland and thyroid cancer cells expressing sodium iodide symporter: initial feasibility study.
CLI clearly demonstrated RI uptake in thyroid gland and xenografted ARO-NIS cells in mice, and a strong positive correlation was observed between CLI intensity and radioactivity assessed by NI. Expand
pH-responsive assembly of gold nanoparticles and "spatiotemporally concerted" drug release for synergistic cancer therapy.
A new combination cancer therapy platform that consists of relatively small 10 nm pH-responsive spherical gold nanoparticles and conjugated doxorubicins that exhibit a synergistic effect enhanced by nearly an order of magnitude in cellular level is reported. Expand
In vivo imaging of tumor apoptosis using histone H1-targeting peptide.
The results suggest that ApoPep-1 holds great promise as a probe for in vivo imaging of apoptosis, while histone H1 is a unique molecular signature for this purpose. Expand
Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis.
  • S. Han, M. Noh, +4 authors K. Park
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1 November 2017
In vivo evidence is provided that Cse deficiency impairs renal the H2S- and GSH-producing activity and exacerbates UUO-induced kidney fibrosis, which proposes a novel therapeutic approach against CKD by regulating CSE and the transsulfuration pathway. Expand
Luminescence imaging using radionuclides: a potential application in molecular imaging.
Many radionuclides with high energetic β(+) or β(-) particles during decay were found to be imaged in luminescence mode due mainly to Cerenkov radiation, providing a new optical imaging platform and an invaluable bridge between optical and nuclear imaging. Expand