Jeong Woo Choi

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Hypoxic damage to the prefrontal cortex (PFC) has been implicated in the frontal lobe dysfunction found in various neuropsychiatric disorders. The underlying subcortical mechanisms, however, have not been well explored. In this study, we induced a PFC-specific hypoxia-like damage by cobalt-wire implantation to demonstrate that the role of the mediodorsal(More)
We analyze the pattern of inter-regional functional association between cortical activities during auditory oddball tasks, and the influence of task difficulty on it. Event-related electroencephalograms were recorded from 17 subjects during auditory oddball tasks with two task difficulty levels. The task difficulty was controlled by changing the difference(More)
The difference in cortical mechanisms underlying processing different languages has been of great interest. Exploration of local and global functional connections between neuronal activities originating from task-relevant areas can contribute to a more complete understanding on these processes. Semantic processing is known to involve frontal and parietal(More)
BACKGROUND Restless legs syndrome (RLS) is a sensorimotor neurological disorder characterized by an irresistible urge to move the legs. It has been reported that RLS patients show cognitive deficits, presumably due to hyperactivity causing loss of attention, or malfunctions in the frontal region resulting from sleep deprivation. However, the mechanism(More)
OBJECTIVE To evaluate the efficacy of transcranial direct current stimulation (tDCS) in people with drug-naïve restless legs syndrome (RLS). METHODS A two-week, double-blind, randomized, sham-controlled trial was performed. Thirty-three females with RLS were recruited. Participants received five sessions of tDCS using cathodal, anodal or sham stimulation.(More)
OBJECTIVES We recently reported that the P300 amplitude related to the Sternberg working memory (WM) task was significantly lower in drug-naïve severe restless legs syndrome (RLS) patients than controls. Here, we evaluated the effects of pramipexole on the Sternberg WM task performance by event-related potential (ERP) study. METHODS Thirteen drug-naïve(More)
OBJECTIVE The aim of this study was to investigate whether there is a working memory (WM) deficit in restless legs syndrome (RLS) patients, by studying the Sternberg WM task of event-related potential (ERP). METHODS Thirteen drug-naive RLS patients and 13 healthy age-matched controls with no sleep disturbances participated in the present study. P300 ERP(More)
Mismatch negativity (MMN) is a negative component of event-related potential (ERP) that reflects auditory deviant detection. Previous studies repeatedly suggested that MMN is generated by the fronto-temporal network. However, it is still unclear how the frontal and temporal areas interact. To verify this, we observed the spatiotemporal pattern of(More)
Self expandable metal stent can be used both as palliative treatment for malignant colorectal obstruction and as a bridge to surgery in patients with potentially resectable colorectal cancer. Here, we report a case of successful relief of malignant stomal obstruction using a metal stent. A 56-year-old man underwent loop ileostomy and was given palliative(More)
In the present study, we fabricated a hemoglobin/gold nanoparticle (Hb/GNP) heterolayer immobilized on the Au micro-gap to confirm H₂O₂ detection with a signal-enhancement effect. The hemoglobin which contained the heme group catalyzed the reduction of H₂O₂. To facilitate the electron transfer between hemoglobin and Au micro-gap electrode, a gold(More)