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TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation
It is reported that a 14-3-3–binding protein, TAZ (transcriptional coactivator with PDZ-binding motif), coactivates Runx2- dependent gene transcription while repressing PPARγ-dependent gene transcription, indicating that TAZ functions as a molecular rheostat that modulates MSC differentiation.
TAZ Promotes PC2 Degradation through a SCFβ-Trcp E3 Ligase Complex
A common role of TAZ is established across vertebrate species in a protein degradation pathway regulated by phosphorylation and implicate deficiencies in this pathway in the development of PKD.
The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members.
Differential association of TEF-1 proteins with transcriptional co-activators may regulate the activity of TEf-1 family members, and differential interaction also extended to the interaction of TEFs and RTEFs with TAZ in vivo, as assayed by a modified mammalian two-hybrid experiment.
Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508
T-betS508 is required for the optimal repression of IL-2 production in developing Th1 cells and its down-regulation in later stages of Th development is reported.
TAZ as a novel enhancer of MyoD‐mediated myogenic differentiation
It is suggested that TAZ functions as a novel transcriptional modulator of myogenic differentiation by promoting MyoD‐mediated myogenic gene expression and enforced coexpression of TAZ and MyOD in fibroblasts accelerates Myo D‐induced myogenic differentiate.
Retinal and choroidal changes and visual outcome in central retinal artery occlusion: an optical coherence tomography study.
TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation.
It is proposed that TAZ, as well as a highly related molecule YAP, are functionally, though not structurally, similar to beta-catenin and integrate extracellular, membrane, and cytoskeletal-derived signals to influence mesenchymal stem cell fate.
YAP and TAZ regulate skin wound healing.
- Min-Jung Lee, M. Byun, M. Furutani-Seiki, Jeong-Ho Hong, Han-Sung Jung
- Biology, MedicineJournal of Investigative Dermatology
- 1 February 2014
Small interfering RNA-mediated knockdown of YAP and TAZ markedly delayed the rate of wound closure and reduced the transforming growth factor-β1 (TGF- β1) expression in the wound.
TAZ Interacts with TTF-1 and Regulates Expression of Surfactant Protein-C*
- Kwon-Sik Park, J. Whitsett, T. Di Palma, Jeong-Ho Hong, M. Yaffe, M. Zannini
- BiologyJournal of Biological Chemistry
- 23 April 2004
Developmental and cell-selective regulation of TAZ provides a mechanism by which the activity of TTF-1 on target genes is modulated, and binds to the NH2-terminal domain of T TF-1.