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TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation
It is reported that a 14-3-3–binding protein, TAZ (transcriptional coactivator with PDZ-binding motif), coactivates Runx2- dependent gene transcription while repressing PPARγ-dependent gene transcription, indicating that TAZ functions as a molecular rheostat that modulates MSC differentiation. Expand
TAZ Promotes PC2 Degradation through a SCFβ-Trcp E3 Ligase Complex
A common role of TAZ is established across vertebrate species in a protein degradation pathway regulated by phosphorylation and implicate deficiencies in this pathway in the development of PKD. Expand
The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members.
Differential association of TEF-1 proteins with transcriptional co-activators may regulate the activity of TEf-1 family members, and differential interaction also extended to the interaction of TEFs and RTEFs with TAZ in vivo, as assayed by a modified mammalian two-hybrid experiment. Expand
TAZ as a novel enhancer of MyoD‐mediated myogenic differentiation
  • H. Jeong, S. Bae, +5 authors E. Hwang
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 September 2010
It is suggested that TAZ functions as a novel transcriptional modulator of myogenic differentiation by promoting MyoD‐mediated myogenic gene expression and enforced coexpression of TAZ and MyOD in fibroblasts accelerates Myo D‐induced myogenic differentiate. Expand
Retinal and choroidal changes and visual outcome in central retinal artery occlusion: an optical coherence tomography study.
Investigating the retinal and choroidal changes using spectral-domain optical coherence tomography (SD OCT) and identifying factors associated with visual outcome in eyes with central retinal artery occlusion resulted in inner and outer retinal thickening in the acute stages and subsequent atrophic changes in the inner andouter retina. Expand
TAZ Interacts with TTF-1 and Regulates Expression of Surfactant Protein-C*
Developmental and cell-selective regulation of TAZ provides a mechanism by which the activity of TTF-1 on target genes is modulated, and binds to the NH2-terminal domain of T TF-1. Expand
YAP and TAZ regulate skin wound healing.
Small interfering RNA-mediated knockdown of YAP and TAZ markedly delayed the rate of wound closure and reduced the transforming growth factor-β1 (TGF- β1) expression in the wound. Expand
TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation.
It is proposed that TAZ, as well as a highly related molecule YAP, are functionally, though not structurally, similar to beta-catenin and integrate extracellular, membrane, and cytoskeletal-derived signals to influence mesenchymal stem cell fate. Expand
Leptomeningeal collaterals are associated with modifiable metabolic risk factors
We sought to identify potentially modifiable determinants associated with variability in leptomeningeal collateral status in patients with acute ischemic stroke.
Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation
It is shown that ECM stiffness regulates MSC fate through ERK or JNK activation, and TAZ activation was induced by ERK/JNK activation on a stiff hydrogel because exposure to an ERKor JNK inhibitor significantly decreased the nuclear localization of TAZ, indicating that ECm stiffness-induced ERK-induced JNKactivation is important for TAZ-driven osteogenic differentiation. Expand