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OBJECTIVES Olfactory function is known to be modulated by repeated exposure to odors. The aim of this investigation was whether patients with olfactory loss would benefit from "Training" with odors in terms of an improvement of their general olfactory function. It was hypothesized that olfactory Training should produce both an improved sensitivity towards(More)
Hyposmia is one of the early signs in idiopathic Parkinson's disease (PD). Olfactory stimuli were applied during fMRI scanning to show disease-related modulation of central nervous system structures and to advance our understanding of olfactory dysfunction in PD patients. All participants received either unpleasant stimuli that smelled like rotten eggs or(More)
The olfactory bulb is a highly plastic structure the volume of which partly reflects the degree of afferent neural activity. In this study, 22 patients with post-infectious olfactory deficit, nine participants with post-traumatic olfactory deficit, and 17 healthy controls underwent magnetic resonance volumetry of the olfactory bulb. Patients presented with(More)
UNLABELLED Flavor is a result of the complex combination of olfactory, gustatory and trigeminal sensations perceived during oral processing of foods, including thermal, painful, tactile and/or kinesthetic effects. Aim of this study was to better understand interactions between synchronous tactile (texture) and olfactory (odor) sensations, using a(More)
OBJECTIVE To investigate the outcome of olfactory function in patients with olfactory loss following infections of the upper respiratory tract (post-URTI) or head trauma. DESIGN Retrospective patient-based study. SETTING Smell and Taste Outpatient Clinic at a university hospital. PATIENTS A total of 361 patients (228 women, 133 men) were included. (More)
OBJECTIVES Odor perception does not simply consist in hierarchical processing from transduction to a single "true" cerebral representation. Odor sensation may be modulated by available sensory information during encoding. The present study set out to examine whether the presence of a pure trigeminal stimulus during odor encoding may modulate odor perception(More)
OBJECTIVE To investigate differences between orthonasal and retronasal olfaction in patients with loss of the sense of smell without taste complaints. DESIGN Electrophysiological and psychophysical testing of orthonasal and retronasal olfactory functions. SETTING Outpatient clinics. PATIENTS A series of 18 patients who had olfactory loss due to(More)
To assess olfactory function, various measures are used in clinical routine. In this study, the Sniff Magnitude Test (SMT), a test considering the sniff response to an odor, was applied to patients with olfactory dysfunction (n = 49) and to a control group without subjective olfaction disorder (n = 21). For comparison, the validated "Sniffin' Sticks" test(More)
The olfactory and trigeminal systems play a role in the sensation of odors. The intrinsic optical signal (IOS) imaging method allows visualization of the neuronal activity. The IOS was measured after the nasal epithelium had been exposed to olfactory (H(2)S) and trigeminal (CO(2)) stimuli. The IOS was measured in the area of the middle turbinate. The(More)
BACKGROUND Aim of this study was to investigate whether intranasal anatomy plays a role in intranasal trigeminal sensitivity. MATERIAL AND METHODS A total of 65 healthy subjects (30 female, 35 male) participated in this study (age range 18-35 years). Nasal cavities were assessed using magnetic resonance imaging (MRI). The area of the nasal cavity was(More)