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Large deletions in Xq21 often are associated with contiguous gene syndromes consisting of X-linked deafness type 3 (DFN3), mental retardation (MRX), and choroideremia (CHM). The identification of deletions associated with classic CHM or DFN3 facilitated the positional cloning of the underlying genes, REP-1 and POU3F4, respectively, and enabled the(More)
The suitability of a 16S rRNA-based mycoplasma group-specific PCR for the detection of mycoplasma contamination in cell cultures was investigated. A total of 104 cell cultures were tested by using microbiological culture, DNA fluorochrome staining, DNA-rRNA hybridization, and PCR techniques. A comparison of the results obtained with these techniques(More)
The risk of cross-colonization and subsequent infection by Pseudomonas aeruginosa in holiday camps for cystic fibrosis patients was studied in 91 children by culturing sputum at their arrival, at their departure, 2 months later, and at regular intervals thereafter. The isolated strains were subjected to serotyping, phage typing, pyocin typing, and(More)
—The statistics of the signal quality due to first-order polarization mode dispersion (PMD) in uncompensated systems is analyzed. First, the probability density function (pdf) of the eye-opening penalty (EOP) due to first-order PMD is presented. Based on an analytical relation between factor and EOP, the pdf of the factor is determined. By integration of(More)
  • F. J. van Kuppeveld, K. E. Johansson, +5 authors W. J. Melchers
  • 1994
The use of a 16S rRNA based polymerase chain reaction (PCR) for the detection ofMycoplasma pneumoniae infection was investigated. Sputum samples from 34 patients with respiratory illness and evidence of pneumonia as judged by chest X-ray were analyzed by PCR and microbiological culture. Throat swabs from 14 healthy individuals were used as controls. For(More)
In this study, the prevalence of mycoplasmas in peripheral blood mononuclear cells (PBMC) from HIV-infected individuals was investigated using a mycoplasma genus-specific PCR assay. No mycoplasmas were detected in the PBMC samples from any of the 25 HIV-infected individuals (CDC 2, n = 8; CDC 3, n = 2; CDC 4, n = 15) or ten HIV-seronegative controls. As an(More)
—To improve the networking flexibility in the metropolitan and access area, the granularity in the optical domain has to be increased above that in the core network requiring more channels at lower bit rates. Pure dense wavelength division multiplexing (DWDM) as it is applied in the core does not seem to meet this requirement at affordable cost. We propose(More)
Recently, an rRNA-based polymerase chain reaction (PCR) has been developed for the detection of murine mycoplasmas at both the genus and species level (F. J. M. van Kuppeveld, J. T. M. van der Logt, A. F. Angulo, M. J. van Zoest, W. G. V. Quint, H. G. Niesters, J. M. D. Galama, and W. J. G. Melchers, Appl. Environ. Microbiol. 58:2606-2615, 1992). In this(More)
Since CMOS GSM-radio-transceiver are established on the market a few years ago the next evolutionary step is a complete GSM/GPRS baseband-RF-SoC integration. It promises lowest production cost, easiest board integration and the highest flexibility in system optimization. However, crosstalk from digital into analog and RF blocks is a severe constraint. In(More)