Jens Geisler

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Self-optimization refers to the ability of a mechatronic system to autonomously adapt the way it performs its functions to changing environmental and operational conditions or user demands. In this work we propose to use multiobjective optimal control to enable the self-optimization of the guidance of a rail-bound vehicle. We consider different strategies(More)
Replication of studies in Software Engineering is considered important, but is largely neglected. Because of the lack of published replicated literature, there are few established guidelines for researchers wanting to conduct replicated studies. Specifically, guidelines for transitioning from laboratory studies to large-scale studies are nonexistent.(More)
Having recently identified a so-far unexplored area adjacent to the known binding site of allosteric mitogen-activated protein kinase kinase (MEK) inhibitors, we now report an extension of these studies by combining our new side chains with different MEK inhibitor cores in a modular manner. Replacement of the amide headgroup with inverse sulfonamides(More)
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