Jens Berthelsen

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The Drosophila Homothorax (HTH) and Extradenticle (EXD) are two homeoproteins required in a number of developmental processes. EXD can function as a cofactor to Hox proteins. Its nuclear localization is dependent on HTH. In this study we present evidence of in vivo physical interaction between HTH and EXD, mediated primarily through an evolutionarily(More)
Human PREP1, a novel homeodomain protein of the TALE super-family, forms a stable DNA-binding complex with PBX proteins in solution, a ternary complex with PBX and HOXB1 on DNA, and is able to act as a co-activator in the transcription of PBX-HOXB1 activated promoters (Berthelsen, J., Zappavigna, V., Ferretti, E., Mavilio, F., Blasi, F. , 1998b. The novel(More)
Pseudomonas aeruginosa is a clinically relevant species involved in biofilm-based chronic infections. We provide evidence that the P. aeruginosa LapG protein functions as a periplasmic protease that can cleave the protein adhesin CdrA off the cell surface, and thereby plays a role in biofilm formation and biofilm dispersal. The P. aeruginosa LapG protein is(More)
Type 1 vs type 2 calreticulin mutations in primary myelofibrosis: differences in phenotype and prognostic impact. a multi-process calcium buffering chaperone of the endoplasmic reticulum. Landolfo L et al. The structure of calreticulin C-terminal domain is modulated by physiological variations of calcium concentration. Mutated calreticulin retains(More)
Background Protein Lysine methyltransferases (PKMTs) are group of histone modifiers that are responsible for the transfer of one to three methyl groups from S-adenosyl-L-methionine (AdoMet) to the ε-amino group of the target lysine residues in histones[1] and some non-histone targets[2]. To date more than 50 PKMTs have been identified and EHMT1 (Euchromatic(More)
Binding assays are increasingly used as a screening method for protein kinase inhibitors; however, as yet only a weak correlation with enzymatic activity-based assays has been demonstrated. We show that the correlation between the two types of assays can be improved using more precise screening conditions. Furthermore a marked improvement in the correlation(More)
Testicular biopsy specimens from 4 (8%) of 50 men previously treated for maldescended testes had a carcinoma-in-situ pattern. 2 of these men had adjacent invasive carcinoma (seminoma and embryonal carcinoma). The patient with embryonal carcinoma had an enlarged testis but the 3 other patients with neoplasia had no clinical signs or symptoms of malignancy.(More)
[a] Death-associated protein kinase 1 (DAPK1) has been associated with N-methyl-d-aspartate (NMDA) receptor-mediated excito-toxicity, and has recently been suggested as a target for the treatment of stroke. Here, we examined DAPK1-mediated in vitro phosphorylation of the GluN2B subunit of NMDA receptors. We established a high-throughput screening assay for(More)
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