Jenny Valladeau-Guilemond

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Dendritic cells (DCs) initiate adaptive immune responses in lymph nodes (LNs). In mice, LN DCs can be divided into resident and tissue-derived populations, the latter of which migrate from the peripheral tissues. In humans, different subsets of DCs have been identified in the blood, spleen, and skin, but less is known about populations of resident and(More)
Human monocyte-derived dendritic cell (MoDC) have been used in the clinic with moderately encouraging results. Mouse XCR1(+) DC excel at cross-presentation, can be targeted in vivo to induce protective immunity, and share characteristics with XCR1(+) human DC. Assessment of the immunoactivation potential of XCR1(+) human DC is hindered by their paucity in(More)
Specific mesenchymal markers are retained and hematopoietic markers are not up-regulated by a 30 Gray-irradiation on infant foreskin fibroblasts that still respond to pro-inflammatory cytokines. (A) After 3-5 passages, the expression of surface markers was analyzed by flow cytometry on γ-FFs that were cultured for 24 h under an identical seeding(More)
Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC functions. Here, we show that human NK cells promote cross-presentation of tumor cell-derived Ag by DC leading to Ag-specific CD8(+)(More)
E. Verron ese, A. Delgado, J. Valladeau-Guilemond, G. Garin, S. Guillemaut, O. Tredan, I. Ray-Coquard, T. Bachelot, A. N’Kodia, C. Bardin-Dit-Courageot, C. Rigal, D. P erol, C. Caux, and C. M en etrier-Caux Innovation in Immuno-monitoring and Immunotherapy Platform (PI3), L eon B erard Cancer Center, Lyon, France; Team 11, INSERM U1052/CNRS UMR5286, Cancer(More)
Langerin, a trimeric C-type lectin specifically expressed in Langerhans cells, has been reported to be a pathogen receptor through the recognition of glycan motifs by its three carbohydrate recognition domains (CRD). In the context of HIV-1 (human immunodeficiency virus-1) transmission, Langerhans cells of genital mucosa play a protective role by(More)
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