Jenny Valladeau-Guilemond

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Dendritic cells (DCs) initiate adaptive immune responses in lymph nodes (LNs). In mice, LN DCs can be divided into resident and tissue-derived populations, the latter of which migrate from the peripheral tissues. In humans, different subsets of DCs have been identified in the blood, spleen, and skin, but less is known about populations of resident and(More)
Monitoring functional competence of immune cell populations in clinical routine represents a major challenge. We developed a whole-blood assay to monitor functional competence of peripheral innate immune cells including NK cells, dendritic and monocyte cell subsets through their ability to produce specific cytokines after short-term stimulation, detected(More)
DCs are a rare population of professional antigen-presenting cells. Numerous studies have shown that mouse DCs are heterogenous and comprise several subtypes with distinct phenotype and functional properties (Heath and Carbone, 2009). DCs can be divided into two main groups: conventional (cDCs) and plasma-cytoid DCs (pDCs). In the steady-state, committed DC(More)
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