Jenny Owen

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The effect of reboxetine on norepinephrine (NE) efflux in the frontal cortex of freely moving rats has been studied using in vivo microdialysis. Reboxetine was administered either by injection (10 and 30 mg/kg i.p.) or directly to the frontal cortex via the dialysis probe (10 and 100 microM). To further elucidate the mechanism of action of reboxetine in(More)
NMDA receptors play a role in the aetiology of depression with non-competitive NMDA receptor antagonists such as amantadine showing synergy with conventional antidepressants. To advance a neurochemical rational for these findings, we have studied the effects of administration of amantadine and budipine with the antidepressants reboxetine (REB), paroxetine(More)
Events of the Paleocene-Eocene boundary provide the clearest example to date of how a tectonic event may have global climatic consequences. Recent advances permit well-constrained stratigraphic determination of several events that occurred at that boundary, in chron C24R: a many-fold increase in sea-floor hydrothermal activity, a global warming, a reduction(More)
We present new UK research (1987-90) in the area of gender and office information systems design. Our paper will contribute to the CSCW debate in two areas. Methodology, where we use our case-study experiences to reflect upon the traditional computing approaches to office systems design. Secondly, participatory design, through our active involvement in the(More)
1. Evidence has recently suggested that NMDA receptors may play a role in the aetiology and possible treatment of depression and that weak noncompetitive NMDA receptor antagonists such as amantadine can synergize with conventional antidepressants in a model of the illness. 2. To try to obtain a neurochemical rationale for these findings, we have studied the(More)
Treatment of depression is largely based upon the monoamine theory of the illness. However, current therapies are only efficacious in 70-80% of patients indicating that other factors are involved. One mechanism could involve glutamatergic NMDA receptors since NMDA receptor antagonists have antidepressant like properties in paradigms of the illness. We have(More)
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