Jenny J. Lin

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T cells discriminate between self and foreign antigenic peptides, displayed on antigen presenting cell surfaces, via the TCR. While the molecular interactions between TCR and its ligands are well characterized in vitro, quantitative measurements of these interactions in living cells are required to accurately resolve the physical mechanisms of TCR(More)
PURPOSE Little is known about why women with breast cancer who have surgery do not receive proven effective postsurgical adjuvant treatments. METHODS We surveyed 258 women who recently underwent surgical treatment at six New York City hospitals for early-stage breast cancer about their care, knowledge, and beliefs about breast cancer and its treatment. As(More)
An important determinant of [H(+)] in the environment of the central chemoreceptors is cerebral blood flow. Accordingly we hypothesized that a reduction of brain perfusion or a reduced cerebrovascular reactivity to CO(2) would lead to hyperventilation and an increased ventilatory responsiveness to CO(2). We used oral indomethacin to reduce the(More)
RATIONALE Minority patients with lung cancer are less likely to receive stage-appropriate treatment. Along with access to care and provider-related factors, cultural factors such as patients' lung cancer beliefs, fatalism, and medical mistrust may help explain this disparity. OBJECTIVES To determine cultural factors associated with disparities in lung(More)
The National Lung Screening Trial (NLST) recently reported that annual computed tomography (CT) screening is associated with decreased lung cancer mortality in high-risk smokers. Beliefs about lung cancer and screening, particularly across race and ethnicity, and their influence on CT screening utilization are largely unexamined. Our study recruited(More)
RATIONALE Prior studies have shown an anticancer effect of metformin in patients with breast and colorectal cancer. It is unclear, however, whether metformin has a mortality benefit in lung cancer. OBJECTIVES To compare overall survival of patients with diabetes with stage IV non-small cell lung cancer (NSCLC) taking metformin versus those not on(More)
OBJECTIVES Physicians frequently express dissatisfaction about caring for patients with chronic pain and frequently report that inadequate training and concern about addiction are impediments to prescribing opioids. Elderly patients with chronic pain may be at increased risk of experiencing uncontrolled pain and this patient population is increasingly being(More)
Failure to follow up outpatient test results in a timely manner is a growing patient safety concern. To investigate the follow-up of markedly elevated serum potassium levels in the ambulatory setting, the authors reviewed the medical records of all patients seen in a large primary care practice between September 1, 2003, and August 31, 2004, with potassium(More)
BACKGROUND Few studies have investigated the time it takes physicians to follow up abnormal outpatient laboratory results. METHODS Medical record review of all adult patients seen at a primary care practice between January 2002 and December 2005 with serum potassium results > or = 6.0 mEq/L. We used a proportional hazards model to assess factors(More)
Author Affiliations:Division of General Medicine, Department of Medicine, Massachusetts General Hospital, and HarvardMedical School, Boston (Chinn); Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts (Liu, Keating); Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland (Klabunde);(More)