Jenny Guek Hong Low

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Polymyxin B is increasingly used clinically for the treatment of multidrug-resistant Gram-negative infections, despite very limited understanding of its disposition in humans. The disposition of intravenous polymyxin B1 in 9 adult patients was characterized. Random blood samples (specifically timed in relation to the dose administered) were obtained, and(More)
Twenty-one patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa pneumonia were treated with nebulized polymyxin E (colistin). Overall clinical and microbiological response rates were 57.1% and 85.7%, respectively. Nebulized colistin may be reasonably efficacious and safe for treatment of MDR pneumonia. Its role in(More)
A study of the prevalence and epidemiology of Panton-Valentine leukocidin-producing Staphylococcus aureus in a tertiary public hospital was conducted. The incidence of gene carriage among S. aureus strains causing disease was 11.6%. Results were significant for the higher incidence of gene carriage, compared with those found in previous studies.
STUDY OBJECTIVE To describe the clinical characteristics and outcome of patients with severe melioidosis requiring intensive care. DESIGN Retrospective chart review. SETTING Two ICUs from a tertiary-care teaching hospital. PATIENTS Twenty-seven adult ICU patients with microbiologically documented melioidosis. INTERVENTIONS None. MEASUREMENTS AND(More)
BACKGROUND Patients with neutropenic fever after 4-7 days of broad-spectrum antibiotics are given antifungals empirically. This strategy may lead to over-treatment. METHODS Patients with hematological malignancies undergoing intensive chemotherapy or hematopoietic stem cell transplantation were randomized to two arms. Patients in the 'preemptive' arm had(More)
Multidrug resistance (MDR) in Gram-negative bacteria is on the rise, but its effect on patient outcomes is not well established. The outcomes of 129 adult surgical intensive care unit (SICU) patients treated for Gram-negative pneumonia were evaluated in relation to demographics, bacterial etiology, and infections due to MDR bacteria (defined as resistant to(More)
Melioidosis caused by Burkholderia pseudomallei infection is endemic in Southeast Asia and Northern Australia. Cardiovascular complications resulting in mycotic aneurysms are very rare. To our knowledge, there have only been 6 isolated case reports published in the literature to date. We report 6 cases of melioidosis in Singapore that presented as aortic(More)
Despite advances in surveillance strategies and antivirals, cytomegalovirus (CMV) infection continues to pose problems to patients receiving hematopoietic stem cell transplants (HSCTs). The bone marrow transplant (BMT) unit at the Singapore General Hospital embraced the preemptive strategy in late 2003. Although several studies have demonstrated its(More)
INTRODUCTION Stenotrophomonas maltophilia is an emerging pathogen in nosocomial infections that may result in high mortality. S. maltophilia often present as part of a polymicrobial culture and it is not well established when treatment is indicated. We aimed to identify predictors of mortality in patients with positive cultures of S. maltophilia. (More)