Jenny Grillo

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The sequential events leading to tumor progression include a switch to the angiogenic phenotype, dependent on a shift in the balance between positive and negative angiogenic regulators produced by tumor and stromal cells. While the biological properties of many angiogenesis regulatory proteins have been studied in detail, the mechanisms of their transport(More)
To the Editor: The Breast cancer susceptibility-1 gene (BRCA1) encodes a nuclear protein whose functions include the maintenance of genomic stability, DNA repair, and cell cycle regulation (1). Statistical evidence indicates that women carrying just one mutated BRCA1 allele have a significantly increased risk for developing breast or ovarian cancer (2).(More)
Tumors implanted near the scapulae have been shown to grow four times faster than the same tumors implanted at the iliac crest. Although there were marked differences in the vascularization of tumors from these two different sites, the mechanism controlling regional angiogenesis was not identified. Here, we show site-specific growth of intraperitoneal tumor(More)
ownload ors implanted near the scapulae have been shown to grow four times faster than the same tumors ted at the iliac crest. Although there were marked differences in the vascularization of tumors from two different sites, the mechanism controlling regional angiogenesis was not identified. Here, we show ecific growth of intraperitoneal tumor implants in(More)
The sequential events leading to tumor progression include a switch to the angiogenic phenotype, dependent on a shift in the balance between positive and negative angiogenic regulators produced by tumor and stromal cells. Although the biologic properties of many angiogenesis regulatory proteins have been studied in detail, the mechanisms of their transport(More)
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