Jenny E. Kuipers

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Translocations involving nucleoporin 98kD (NUP98) on chromosome 11p15 occur at relatively low frequency in acute myeloid leukemia (AML) but can be missed with routine karyotyping. In this study, high-resolution genome-wide copy number analyses revealed cryptic NUP98/NSD1 translocations in 3 of 92 cytogenetically normal (CN)-AML cases. To determine their(More)
BACKGROUND miRNAs regulate gene expression, and thus play an important role in critical cellular processes. Aberrant miRNA expression patterns have been found in various types of cancer. So far, information about the expression of miRNAs in pediatric acute myeloid leukemia is limited. PROCEDURE We studied expression of miR-29a, -155, -196a, and -196b by(More)
Pediatric mixed-lineage leukemia (MLL)-rearranged acute monoblastic leukemia with t(9;11)(p22;q23) has a favorable outcome compared with other MLL-rearranged AML. The biologic background for this difference remains unknown. Therefore, we compared gene expression profiles (GEPs; Affymetrix HGU133 + 2.0) of 26 t(9;11)(p22;q23) patients with 42 other(More)
1 Pediatric Oncology/Hematology, Erasmus MC/Sophia Children’s Hospital, Rotterdam, The Netherlands; 2 Pediatric Hematology/Oncology, 2nd Medical School, Charles University, Prague, Czech Republic; 3 Hematology, St. Louis Hospital, Paris, France; 4 Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands; 5 Pediatric Oncology/Hematology, Beatrix(More)
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