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BACKGROUND Only 15-20% of patients with chronic hepatitis C achieve a sustained virological response with interferon therapy. The aim of this study was to compare the efficacy and safety of interferon alpha2b in combination with oral ribavirin with interferon alone, for treatment of chronic infection with hepatitis C virus (HCV). METHODS 832 patients aged(More)
"e" is a serum antigen associated with type-B hepatitis. It is found only in hepatitis B surface antigen (HBsAg) positive sera, but is antigenically distinct from HBsAg. e antigen was not detected in the serum of any of 99 cases of acute type-B hepatitis who recovered normally. Its antibody, anti-e, was found in 14 (14%). The antibody usually appeared(More)
SUMMARY Using a radioimmunoassay technique serum alpha-fetoprotein could be detected in healthy adults in concentrations of less than 20 ,ug/l. Of patients with acute, viral hepatitis 43 % exhibited a transient rise of serum alpha-fetoprotein, the peak occurring eight to nine days after the maximum recorded serum aspartate transaminase activity. Patients(More)
OBJECTIVE To develop a natural history model for chronic hepatitis C virus (HCV) infection to determine allocation of compensatory funds to Canadians who acquired HCV through the blood supply from 1986 through 1990. METHODS A Markov cohort simulation model for HCV prognosis was developed, using content experts, published data, posttransfusion look-back(More)
BACKGROUND Gene expression profiling has the potential to unravel molecular mechanisms behind gene regulation and identify gene targets for therapeutic interventions. As microarray technology matures, the number of microarray studies has increased, resulting in many different datasets available for any given disease. The increase in sensitivity and(More)
This guideline has been approved by the AASLD and represents the position of the association. Preamble These recommendations provide a data-supported approach to the management of primary biliary cirrhosis (PBC). They are based on the following: (1) formal review and analysis of the recently published world literature on the topic (Medline search); (2)(More)
Introduction The Diploma of the Faculty of Sexual and Reproductive Healthcare (DFSRH) is considered to be the gold standard for training in sexual and reproductive health (SRH). Educationalists are realising the potential of using e-learning technologies to support learner-centred training programmes in line with 21st century models of learning, teaching(More)
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