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Effect of Solvents on the Time-Dependent Inhibition of CYP3A4 and the Biotransformation of AZD3839 in Human Liver Microsomes and Hepatocytes
Time-dependent inhibition (TDI) of the cytochrome P450 (P450) family of enzymes is usually studied in human liver microsomes (HLM) by investigating whether the inhibitory potency is increased withExpand
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Quantification of the mutagenic potency and repair of glycidol-induced DNA lesions.
Glycidol (Gly) is an electrophilic low-molecular weight epoxide that is classified by IARC as probably carcinogenic to humans. Humans might be exposed to Gly from food, e.g. refined vegetable oils,Expand
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Cancer Risk Assessment of Glycidol : Evaluation of a Multiplicative Risk Model for Genotoxic Compounds
Humans are exposed to chemical compounds in everyday life, both from the environment and from endogenous processes. Some compounds constitute a risk for cancer development. One such compound is glyExpand
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P03-063Mutagenicity and DNA repair of glycidol-induced adducts in mammalian cells and dose measurements using the cob(I)alamin trapping method
s / Toxicology Letters 238S (2015) S56–S383 S109 and can contaminate food, feeds and specific indoor environments resulting in high economic losses. Severe health problems and death have been relatedExpand