Jenny A Wilkinson

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BACKGROUND Teens and young adults in the United States are in need of sexual and reproductive health information, as evidenced by elevated rates of sexually transmitted infections (STIs), pregnancy, and births among this population. In-person sexuality education programs are helpful, but they are unlikely to rapidly accommodate teens and young adults in a(More)
Mutations in the presenilin 1 (PS1) gene lead to early-onset Alzheimer's disease with the S170F mutation causing the earliest reported age of onset. Expression of this, and other PS1 mutations, in SH-SY5Y cells resulted in significant loss of cellular viability compared to control cells. Basal Ca2+ concentrations in PS1 mutants were never lower than(More)
Prolonged hypoxia alters various cellular processes, including Ca2+ signalling. As these effects can be prevented by antioxidants, we examined the role of glutathione, the major intracellular redox buffer, in modulation of Ca2+ signalling in the human neuroblastoma SH-SY5Y by hypoxia. Rises of [Ca2+]i evoked by bradykinin, and subsequent capacitative Ca2+(More)
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