In this study, we investigated the possible link between lipid peroxidation (LPO) and the formation of protein carbonyls (PCOs) during depletion of brain glutathione (GSH). To this end, rat brain slices were incubated with the GSH depletor diethyl maleate (DEM) in the absence or presence of classical LPO scavengers: trolox, caffeic acid phenethyl ester… (More)
2 We would like to acknowledge and especially thank Dr. Andrew Dannenberg, Centers for Disease Control and Prevention, for his guidance throughout this process and whose help was invaluable in organizing and completing this work. Many people contributed to the report and we would like to thank the following individuals and organizations for their… (More)
Using immunohistochemistry and the monoclonal antibody C219 we have investigated P-glycoprotein expression in 26 locally advanced breast cancers. Twenty four patients had received four cycles of chemotherapy (mitozantrone, mitomycin-C and methotrexate) prior to mastectomy; two received tamoxifen. Twelve tumours exhibited an objective response to the… (More)
OBJECTIVE While the use of multimedia methods in medical education and decision support can facilitate learning, it also has certain hazards. One potential hazard is the inadvertent triggering of racial and gender bias by the appearance of actors or patients in presentations. The authors hypothesized that race and gender affect preferences. To explore this… (More)
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Perspectives I n this issue of PLoS Medicine, Lundy Braun and colleagues from the Race, Medicine, and Science Workshop discuss " the trouble with race " . They argue that the heterogeneity of racial and ethnic categories (and a lack of consensus on how these categories should be defi ned and measured) make them poor markers for underlying differences in… (More)
The human c-myc proto-oncogene is the genomic homologue of the transforming sequences found in MC29, an avian retrovirus that can cause myelocytomatosis, carcinoma, sarcoma and lymphoma (Graf & Beug, 1978; Enrietto et al., 1983). Alterations in the structure or expression of c-myc have been associated with several forms of neoplasia including avian leukosis… (More)