Jennifer Sgro

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We report an improved draft nucleotide sequence of the 2.3-gigabase genome of maize, an important crop plant and model for biological research. Over 32,000 genes were predicted, of which 99.8% were placed on reference chromosomes. Nearly 85% of the genome is composed of hundreds of families of transposable elements, dispersed nonuniformly across the genome.(More)
We investigated the biochemical and clinical efficacy of dietary erucic acid (C22:1) therapy for X-linked adrenoleukodystrophy (ALD). In a double-blind crossover study of patients who were on chronic oleic acid (C18:1) therapy, addition of erucic acid to the diet led to a further reduction in plasma hexacosanoic acid (C26:0) concentration. We treated 12(More)
The effect on rat brain of a large number of stimulations with a high strength pulsed magnetic field was investigated in 31 rats: 10 naive controls, 10 anesthetized controls, and 11 stimulated and anesthetized rats. An investigational magnetic stimulating device with a circular 5.5 inch diameter stimulating head was used. The stimulating coil was energized(More)
Despite the significant morbidity and mortality associated with status epilepticus (SE), little is known about changes in cortical function that occur after SE. We evaluated cortical function after clinical SE using continuous EEG monitoring lasting at least 24 h in 180 patients admitted to the Medical College of Virginia Hospitals (MCVH). The major EEG(More)
Short-latency components of median nerve somatosensory evoked potentials are generally assumed to be unaffected by sleep and level of arousal. We found that sleep prolongs the latency and alters the morphology of the N20 component in normal subjects. These changes may represent differential effects of sleep on various elements contributing to generation of(More)
Standard techniques for evoked potential recording extract a stimulus-locked event from accompanying noise by averaging a large number of sequentially obtained responses. This approach is valid only to the extent that the nervous system's electrical response to successive stimuli is identical. The technique is suboptimal for recording unstable evoked(More)
The diagnostic use of magnetic brain stimulation has not been extensive because of several technical drawbacks. These include the relatively low field strength and low repetition rate of available stimulators, design problems which can be resolved with the construction of stronger and faster magnetic stimulators. The present study details the design of a(More)
While standard evoked potential recording techniques reliably attenuate gaussian and white noise, they are not similarly effective in reducing coherent noise such as that induced by power lines. We have presented a technique that will effectively eliminate coherent noise. This technique is especially appealing for clinical settings where 60 Hz artifact and(More)
We utilized somatosensory evoked potentials to evaluate 33 patients with status epilepticus who did not have focal neurological etiologies. Eighteen percent of the patients had conventional stimulation evoked potential abnormalities at or above the P14 lemniscal level. Evoked potential abnormalities in this population showed a statistically significant(More)
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