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  • Amy Hennigan, Charlotte K. Callaghan, John Kealy, Jennifer Rouine, Áine M. Kelly
  • Psychology, Medicine
  • Behavioural Brain Research
  • 2009 (First Publication: 1 February 2009)
  • We have previously reported that a genetically hypertensive strain of Wistar rat (GH), is deficient in nerve growth factor (NGF) and Trk receptors in dentate gyrus and that these deficits areContinue Reading
  • Shane Patrick Gormley, Jennifer Rouine, Allison L. McIntosh, Christian M. Kerskens, Andrew Harkin
  • Psychology, Medicine
  • Physiology & Behavior
  • 2016 (First Publication: 1 June 2016)
  • Alterations in astrocyte number and function have been implicated in the pathophysiology of a number of psychiatric disorders. The development of magnetic resonance imaging (MRI) as a tool in theContinue Reading
  • Valentina Gigliucci, Shane Patrick Gormley, Sinead M. Gibney, Jennifer Rouine, Andrew Harkin
  • Psychology, Medicine
  • European Neuropsychopharmacology
  • 2014 (First Publication: 1 August 2014)
  • Nitric oxide synthase (NOS) inhibitors possess antidepressant-like properties in preclinical tests and in the current investigation the brain penetrant NOS inhibitor N(ω)-nitro-L-arginine (l-NA) andContinue Reading
  • Jennifer Rouine, Oliviero L Gobbo, +10 authors Andrew Harkin
  • Medicine, Chemistry
  • British journal of pharmacology
  • 2013 (First Publication: 1 July 2013)
  • BACKGROUND AND PURPOSE The purpose of this study was to assess cerebral perfusion changes following systemic administration of the recreational drug 3,4-methylendioxymethamphetamine (MDMA 'ecstasy')Continue Reading
  • Charlotte K. Callaghan, Jennifer Rouine, Reginald L. Dean, Brian I. Knapp, Shane M. O'Mara
  • Medicine, Biology
  • Brain, Behavior, and Immunity
  • 2018
  • Patients receiving the cytokine immunotherapy, interferon-alpha (IFN-α) frequently present with neuropsychiatric consequences and cognitive impairments. Patients (25-80%) report symptoms ofContinue Reading
  • Jennifer Rouine, Melanie E. M. Kelly, +5 authors Andrew Harkin
  • Psychology, Medicine
  • Psychopharmacology
  • 2014 (First Publication: 1 May 2015)
  • RationaleAcute administration of the recreational drug of abuse 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) has previously been shown to increase cerebro-cortical perfusion as determined byContinue Reading
  • Charlotte K. Callaghan, Jennifer Rouine, +5 authors Shane M. O'Mara
  • Biology
  • 2019 (First Publication: 28 September 2019)
  • Rationale: Many patients respond inadequately to antidepressant drug treatment; the search for alternate pharmacological treatment mechanisms is ongoing. Until the 1950s, opium was sometimes used toContinue Reading