Jennifer R. Rider

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Circadian genes may be involved in regulating cancer-related pathways, including cell proliferation, DNA damage response, and apoptosis. We aimed to assess the role of genetic variation in core circadian rhythm genes with the risk of fatal prostate cancer and first morning void urinary 6-sulfatoxymelatonin levels. We used unconditional logistic regression(More)
Observational studies report conflicting results on the association between metformin exposure and prostate cancer outcomes. This meta-analysis summarizes studies reporting overall survival, prostate cancer-specific mortality, and biochemical recurrence. PubMed and Embase were systematically reviewed to identify studies investigating the association between(More)
Molecular research in cancer is one of the largest areas of bioinformatic investigation, but it remains a challenge to understand biomolecular mechanisms in cancer-related pathways from high-throughput genomic data. This includes the Nuclear-factor-kappa-B (NFκB) pathway, which is central to the inflammatory response and cell proliferation in prostate(More)
Recent studies suggest variation in genes along the vitamin D pathway, as well as vitamin D receptor (VDR) protein levels, may be associated with prostate cancer. As serum vitamin D levels vary by season, we sought to determine whether the expression of genes on the vitamin D pathway, assessed in prostate tumor tissue, do the same. Our study incorporates(More)
Higher Gleason grade is associated with prostate cancer mortality; however, there is significant heterogeneity in this association. We evaluated whether vessel morphology, a biomarker of angiogenesis, aided in distinguishing mortality risks among men with high Gleason grading. We characterized vessel morphology (area and irregularity) among 511 patients(More)
BACKGROUND Understanding the biologic mechanisms underlying the development of lethal prostate cancer is critical for improved therapeutic and prevention strategies. In this study we explored the role of tumor metabolism in prostate cancer progression using mRNA expression profiling of seven metabolic pathways; fatty acid metabolism,(More)
Prostate cancer is the most common cancer among men in Western countries but the exact pathogenic mechanism of the disease is still largely unknown. An infectious etiology and infection-induced inflammation has been suggested to play a role in prostate carcinogenesis and Propionibacterium acnes has been reported as the most prevalent microorganism in(More)
OBJECTIVE  To determine the inherited factors associated with the ability to smell asparagus metabolites in urine. DESIGN  Genome wide association study. SETTING  Nurses' Health Study and Health Professionals Follow-up Study cohorts. PARTICIPANTS  6909 men and women of European-American descent with available genetic data from genome wide association(More)
BACKGROUND The expansion of combination antiretroviral treatment (ART) in southern Africa has dramatically reduced mortality due to AIDS-related infections, but the impact of ART on cancer incidence in the region is unknown. We sought to describe trends in cancer incidence in Botswana during implementation of the first public ART program in Africa. (More)
The images for Figs 3 and 6 are incorrectly switched. The image that appears as Fig 3 should be Fig 6, and the image that appears as Fig 6 should be Fig 3. The figure captions appear in the correct order. Please see the corrected figures here. Fig 3. Trend in standardized incidence ratio (SIR) of cancer comparing HIV infected and HIV uninfected populations(More)