Jennifer R Blair

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We report the successful grafting of embryonic (newborn) rat retina into a lesion site (die-back zone) of an adult retina with a corresponding 90-100% survival rate. A penetrating lesion was made through the sclera, choroid and retina on the superior surface of the host eye and closed with microsutures. The lesion site was either allowed to stabilize for 5(More)
The mu-opioid receptor displays basal signaling activity, which seems to be enhanced by exposure to opioid agonists. This study assesses the in vivo pharmacology of the putative "neutral" antagonist 6beta-naltrexol in comparison to other ligands with varying efficacy, such as naloxone, an inverse agonist in the opioid-dependent state. ICR mice were used to(More)
OBJECTIVE To assess the electrocardiographic safety profile of low-dose ziprasidone (< or =40 mg/day) among pediatric outpatients treated for up to 6 months. METHOD This was a prospective, open-label trial involving 20 subjects with a mean age of 13.2 +/- 3.0 years. Subjects received a mean ziprasidone dose of 30 +/- 13 mg/day and were followed for 4.6(More)
We have previously reported the successful transplantation of neonatal rat retina to the lesioned retinas of adult host rats. The current studies provide a much more in-depth evaluation of the optimal conditions under which successful grafting can be achieved. Utilizing the same surgical approach and techniques as in our earlier studies, the variables of(More)
A lesion paradigm involving a small penetrating incision made through the sclera, choroid and retina of the adult rat eye creates a unique environment for the study of the damaged retina. More specifically, the dependable formation of a small focal retinal lesion makes this an ideal model for the determination of conditions that may stimulate retinal(More)
A small penetrating incision made through the sclera, choroid and retina of the adult rat eye creates a unique lesion paradigm. More specifically, by one to two weeks after the incision the wound area stabilizes, leaving a clean inflammation-free degeneration gap or 'die-back zone' (200-300 microns wide) between the cut edges of the intact retina. The(More)
From the review of the current literature it is quite evident that some exciting prospects are on the horizon which will help to better explain the development and functioning of the visual system. In addition, the new technology of CNS tissue grafting coupled to other newly emerging technologies (i.e., microsurgical, microinjection, and micromanipulative(More)