Jennifer Quinn McCann

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The effect of trimethoprim (TMP) on serum creatinine concentration (SCr) was studied in 10 healthy (H) subjects and nine subjects with chronic renal failure (CRF). Each volunteer was given TMP 100 mg perorally every 12 h for 10 days followed by a 7-day washout period. SCr was measured colorimetrically immediately before the study (baseline), on day 10 of(More)
Patients with heart disease are frequently treated with supplemental oxygen. Although oxygen can exhibit vasoactive properties in many vascular beds, its effects on the coronary circulation have not been fully characterized. To examine whether supplemental oxygen administration affects coronary blood flow (CBF) in a clinical setting, we measured in 18(More)
This study sought to determine which factors influence the mortality rate in patients developing gastrointestinal complications following cardiac surgery. Between July 1988 and January 1992, 2054 patients underwent cardiac surgical procedures at the Boston University Medical Center. Of these, 29 (1.4%) developed postoperative gastrointestinal complications.(More)
BACKGROUND The optimal steroid dose for patients who require mechanical ventilation (MV) for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is unknown. OBJECTIVE The primary objective of the study is to describe the relationship between steroid doses prescribed and duration of MV. METHODS This was a retrospective study of patients(More)
In 10 patients who underwent percutaneous coronary intervention involving the right coronary artery, a new procedure for adjunctive temporary transfemoral pacing of the left ventricle through the coronary sinus was tested. The procedure was successful in 8 of 10 patients and could be performed in <5 minutes by experienced operators and supervised cardiology(More)
McNulty, Patrick H., Nicholas King, Sofia Scott, Gretchen Hartman, Jennifer McCann, Mark Kozak, Charles E. Chambers, Laurence M. Demers, and Lawrence I. Sinoway. Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization. Am J Physiol Heart Circ Physiol 288: H1057–H1062, 2005;(More)
PURPOSE Two cases of malignant hyperthermia suspected to be related to the use of a nondepolarizing neuromuscular blocker are reported. SUMMARY A pharmacogenetic disorder that may occur in as many as 1 in 3000 anesthesia procedures, malignant hyperthermia has been linked to the use of certain anesthetic gases and depolarizing neuromuscular blocking agents(More)
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