Jennifer Peppe

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BACKGROUND Current antibiotic therapies for Clostridium difficile-associated diarrhea have limitations, including progression to severe disease, recurrent C. difficile-associated diarrhea, and selection for nosocomial pathogens. Tolevamer, a soluble, high-molecular weight, anionic polymer that binds C. difficile toxins A and B is a unique nonantibiotic(More)
Four recent outbreaks of pertussis in Massachusetts illustrate some features that contribute to the increased incidence of the disease. The outbreaks involved unimmunized groups of children with philosophical or religious exemptions from school or day-care immunization requirements and children and adults who were reluctant to undergo antibiotic prophylaxis(More)
This was a 24-week, multicenter phase-2 study designed to assess safety, tolerability, and pharmacodynamics of FBS0701, a novel oral chelator, in adults with transfusional iron overload. Fifty-one patients, stratified by transfusional iron intake, were randomized to FBS0701 at either 14.5 or 29 mg/kg/d (16 and 32 mg/kg/d salt form). FBS0701 was generally(More)
A 4-year retrospective study showing that we isolated Bordetella holmesii, but not Bordetella pertussis, from patients with pertussis-like symptoms was performed. From 1995 through 1998, we isolated B. holmesii from 32 nasopharyngeal specimens that had been submitted from patients suspected of having pertussis. Previously, B. holmesii had been associated(More)
A 78-year-old female developed microbial keratitis from which corneal scrapings grew dysgonic fermenter 2. The infection initially responded poorly to a combination of topical antibiotics and corticosteroids but healed with intensive antibiotic therapy. There was no systemic predisposition to infection, and only feline exposure had occurred. Close(More)
The relationship between superstitious beliefs and behaviors, and measures of obsessive-compulsive experiences was examined in this study. Both superstitious beliefs and superstitious behaviors were correlated with measures of compulsivity and obsessionality. Compulsive checking, but not compulsive cleaning (from the MOCI and the CAC-R) were correlated with(More)
A total of 66 isolates of Salmonella javiana isolated from food, food handlers, and patrons that were epidemiologically linked to an outbreak of gastroenteritis were analyzed by pulsed-field gel electrophoresis. Analysis with restriction endonucleases XbaI and SpeI supported the epidemiologic association and suggested a pathway of transmission among food,(More)
AIMS To evaluate the safety and tolerability of a new oral solution formulation of tolevamer potassium sodium, a nonantibiotic polymer that binds Clostridium difficile toxins A and B. METHODS This phase 1 randomized, double-blind, placebo-controlled study evaluated four doses of tolevamer potassium sodium in 40 healthy volunteers using a sequential dose(More)
1Children’s Hospital, Harvard University, Boston, MA; 2Università degli Studi di Cagliari, Cagliari, Italy; 3Siriraj Hospital, Mahidol University, Bangkok, Thailand; 4Pediatric Haematology, Ege University Hospital, Izmir, Turkey; 5Scienze Cliniche e Biologiche, Torino, Italy; 6Gastroenterology, Children’s Hospital & Research Center Oakland, Oakland, CA;(More)
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