Jennifer Movassaghi Moffett

Learn More
BACKGROUND & AIMS Intestinal-type gastric cancer is often preceded by intestinal metaplasia in humans. The genetic events responsible for the transdifferentiation that occurs in intestinal metaplasia are not well understood. Cdx2, a transcription factor whose expression is normally limited to the intestine, has been detected in gastric intestinal(More)
Sucrase-isomaltase (SI), an intestine-specific gene, is induced in the differentiated small intestinal villous epithelium during the suckling-weaning transition in mice. We have previously identified cis-acting elements within a short evolutionarily conserved SI promoter. However, the nature and profile of expression of the interacting proteins have not(More)
BACKGROUND & AIMS Cdx2 is critical in intestinal proliferation and differentiation. Modulation of Cdx2 function in response to cellular signaling is to be elucidated. We hypothesize that phosphorylation of the Cdx2 activation domain can modulate its function. METHODS The Cdx2 activation domain was delineated in transient transfections using different(More)
OBJECTIVE To summarize the indications and techniques for parathyroid autotransplantation and to explore other aspects of the field that warrant further research and discussion. METHODS Review of relevant literature with focus on parathyroid autotransplantation and cryopreservation. RESULTS Parathyroid autotransplantation is an important technique used(More)
BACKGROUND & AIMS Keratins are intermediate filaments that are critical in cytoskeletal organization. Their roles in cellular processes are underscored by inherited human diseases in which germline mutations of keratins are found, as well as by transgenic and knockout mouse models that recapitulate those diseases. Keratin 19 (K19) has unique structural(More)
IMPORTANCE Surgical site infection following stoma reversal (SR) poses a substantial burden to the patient and health care system. Its overall incidence is likely underreported and poorly characterized. Improving our understanding of surgical site infection following stoma reversal may help us identify methods to decrease this complication. OBJECTIVE To(More)
BACKGROUND The incidence of incisional hernias after stoma reversal is not well reported. The aim of this study was to systematically review the literature reporting data on incisional hernias after stoma reversal. We evaluated both the incidence of stoma site and midline incisional hernias. METHODS A systematic review identified studies published between(More)
We used transsexual limb transplants in fiddler crabs to examine how peripheral sensory structures interact with the central nervous system (CNS) to produce a sexually dimorphic behavior. Female and male chemosensory feeding claws were transplanted onto male hosts in place of nonfeeding, nonchemosensory claws. Successfully transplanted claws retain donor(More)
Abdominal wall defects may arise from trauma, infection, and prior abdominal surgeries, such as tumor resections. Although ideally reconstruction should be accomplished as soon as possible to restore the integrity and function of the abdominal wall, it is not always a viable option. A successful reconstruction must take into consideration the local(More)