Jennifer Mosebach

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BACKGROUND Structural and functional oligodendrocyte deficits as well as impaired myelin integrity have been described in affective disorders and schizophrenia, and may disturb the connectivity between disease-relevant brain regions. Olig1, an oligodendroglial transcription factor, might be important in this context, but has not been systematically studied(More)
PET/MRI represents a promising hybrid imaging modality with several potential clinical applications. Although PET/MRI seems highly attractive in the diagnostic approach of multiple myeloma (MM), its role has not yet been evaluated. The aims of this prospective study are to evaluate the feasibility of (18)F-FDG PET/MRI in detection of MM lesions, and to(More)
Aim of this prospective study was to assess the sensitivity of positron emission tomography (PET) and diffusion-weighted imaging (DWI) in detecting multiple myeloma (MM) lesions, using the well-established morphologic modalities magnetic resonance imaging (MRI) and computed tomography (CT) as the standard of reference (RS). The study included 24 MM patients(More)
For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-body computed tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM.(More)
Methods 24 primary and pre-treated patients diagnosed with multiple myeloma according to the International Myeloma Working Group criteria were examined by F-FDG PET/CT and whole-body MRI including DWI (b= 0, and b= 800 s/mm). F-FDG PET/MRI was used to achieve correct matching of findings in the corresponding PET/ CT study. Suspicious lesions were defined by(More)
Die diffusionsgewichtete Bildgebung („diffusion-weighted imaging“, DWI), ein Verfahren aus der Magnetresonanztomographie (MRT), wurde in der klinischen Routine primär für die Detektion von Schlaganfällen etabliert. Der Einsatz dieser Methode hat in den letzten 15 Jahren auch für die onkologische Diagnostik stark zugenommen, da Tumoren und Metastasen(More)
Methods 55 Patients diagnosed according to the International Myeloma Working Group criteria (2003) were referred to consecutive imaging diagnostics including 18F-FDG PET/CT, T1-weighted and short-tau inversion recovery (STIR) whole-body MRI (WB-MRI) as well as diffusion weighted MRI (DWI). Images were reviewed and matched on a lesion-by-lesion basis for the(More)
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