Jennifer Miller

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Although, much progress has been made in our understanding of DC ontogeny and function, the transcriptional regulation of DC lineage commitment and functional specialization in vivo is poorly understood. We performed a comprehensive comparative analysis of CD8+, CD103+, CD11b+, and plasmacytoid DC subsets and the recently identified Macrophage DC precursors(More)
GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells (DCs) and is thought to control the development of inflammatory DCs and resident CD103(+) DCs in some tissues. Here we showed that in contrast to the current understanding, Csf-2 receptor acts in the steady state to promote the survival and homeostasis of nonlymphoid(More)
The cytoplasmic helicase RIG-I is an established sensor for viral 5'-triphosphorylated RNA species. Recently, RIG-I was also implicated in the detection of intracellular bacteria. However, little is known about the host cell specificity of this process and the bacterial pathogen-associated molecular pattern (PAMP) that activates RIG-I. Here we show that RNA(More)
Mapping forest species distributions is notoriously difficult in human-dominated mixed temperate forest environments. The goal of this study is to evaluate the effectiveness of species distribution modeling techniques for estimating the distribution of forest canopy species on Cape Cod, Massachusetts, USA. Binary maps of estimated presence/absence were(More)
Dendritic cells (DCs) serve as the sentinels of the immune system by informing the system about external stimuli, based on which an adaptive response can be mounted. However, not much is known about the genes and their interactions that regulate DC function. Using a large gene expression compendium, we uncover promising regulatory networks underlying the(More)
As companies based in the US launch more "Web 2.0"-style products, the rest of the world may not be moving at the same speed. This presentation will reveal the pitfalls of building the same product for all audiences across many countries, especially when it comes to economic, environmental, technological, and cultural disparities. This illustrates the point(More)
For " Transformers: The Game, " Activision called on Blur to create one high-powered, montage-style open and two alternate endings for their much-anticipated game release. Good and evil battle for ultimate control in an energized edit featuring cool transforming robots, edgy cityscapes, and filmic lighting and compositing. When you have giant robots(More)