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  • Richard John Davis, Joaquin Tosi, +9 authors Stephen H. Tsang
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • 2008 (First Publication: 1 November 2008)
  • PURPOSE Approximately 8% of autosomal recessive retinitis pigmentosa (RP) cases worldwide are due to defects in rod-specific phosphodiesterase PDE6, a tetramer consisting of catalytic (PDE6alpha andExpand
  • Kerstin M. Janisch, Jennifer Mie Kasanuki, +4 authors Stephen H. Tsang
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 2009 (First Publication: 25 December 2009)
  • The gamma subunit of rod-specific cGMP phosphodiesterase 6 (PDE6gamma), an effector of the G-protein GNAT1, is a key regulator of phototransduction. The results of several in vitro biochemicalExpand