Jennifer McNally

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OBJECTIVE To determine the relationship between sperm motility and sperm morphology parameters and IVF and pregnancy rates. DESIGN Pre- and postpreparation analysis of semen samples from infertile couples undergoing IVF-ET. SETTING Andrology Laboratory, Royal Maternity Hospital, Belfast, Northern Ireland. PATIENT(S) One hundred fifty couples(More)
Luminol and lucigenin chemiluminescence (CL) responses produced by separated human blood polymorphonuclear leukocytes (pmn) and monocytes (mono) have been studied following stimulation with the surface-receptor agonist fMLP (a synthetic chemotactic peptide) and the protein kinase C activator phorbol myristate acetate (PMA). Pmn produced two- to threefold(More)
Presenting the characteristics of single-subject research, the authors advocate greater use of the method by clinical nurse specialists and explore issues implicit in the research design (external validity, rigor, statistical versus clinical significance, ethics, and service versus research orientation). Replicated single-subject designs seem well suited to(More)
OBJECTIVE Little is known about the role of mononuclear phagocytes in systemic vasculitis. We examined the hypothesis that monocytes from patients with primary systemic vasculitis have increased capacity to generate reactive oxygen species. METHODS We studied patients with primary systemic vasculitis (n = 24) and compared them with patients with(More)
This study describes the clinical experiences of doctorally prepared nurses whose primary professional role is providing care as advanced practice nurses. Telephone interviews were conducted with 20 participants who lived and practiced in 13 states. Practice settings for these nurses included inpatient acute care and various outpatient/community health(More)
OBJECTIVE To assess the sperm yield and patient acceptability of Trucut needle testicular biopsy followed by seminiferous tubule milking. DESIGN Prospective case analysis. SETTING The Regional Fertility Center, Royal Maternity Hospital, Belfast, Northern Ireland, United Kingdom. PATIENT(S) Forty-one males with obstructive azoospermia (normal(More)
Several authors have shown that neutrophil generation of reactive oxygen species (ROS) declines with advancing age. Similar changes have also been suggested in monocytes. In both cases alterations in second messenger activity have been implicated as the most likely explanation for these observations. The aim of this study was to investigate the effect of(More)
Complete functional deficiency of the phagocytic cell enzyme, myeloperoxidase, is described in a patient with rheumatoid arthritis. Measurement of oxygenation and free radical activity by blood monocytes and polymorphonuclear leucocytes shows gross reduction in myeloperoxidase-dependent chemiluminescence. Implications of these data for theories linking(More)
CASEREPORT ] Mr and Mrs C were aged 35. Mr C worked as a bus driver and his wife as a manageress. He was known to have obstructive azoospermia due to congenital absence of the vas deferens and was a carrier of the cystic fibrosis gene mutation R560T. His karyotype was 46XY and his hormone profile was normal. Mrs C was not a cystic fibrosis carrier, her(More)