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Glutathione depletion achieved by continuous exposure of mitogen-activated human T lymphocytes to L-buthionine-(S,R)-sulfoximine, a specific inhibitor of gamma-glutamylcysteine synthetase, leads to a… Continue Reading
OBJECTIVES Recent data suggest that the bladder urothelium may have a sensory function by way of release of adenosine triphosphate (ATP) during stretch, which then acts as a sensory neurotransmitter.… Continue Reading
Interstitial cystitis (IC) is a disease complex characterized by urinary frequency, urgency, and bladder pain without an identifiable cause. Essentially, IC is a diagnosis of exclusion. The lack of… Continue Reading
S3 nerve root neuromodulation is becoming an accepted therapy for individuals afflicted with lower urinary tract symptoms, such as idiopathic urinary urge incontinence, frequency, urgency, and… Continue Reading