Jennifer M R Baker

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1. Cross-correlation analysis of the discharges of individual motor units recorded from various different finger muscles has been performed during weak, isometric, voluntary contractions in man. 2. The dominant feature in 88% of the cross-correlograms studied was a narrow, central peak, the area of which significantly exceeded that expected for independent(More)
1. Recordings were made of the firing of pairs of intrinsic hand muscle motor units active under different task conditions in man. The different tasks were defined as isometric contractions producing force in one of three different directions: finger abduction, finger extension, or finger flexion. The degree of motor-unit synchronization associated with(More)
Neuropeptide B (NPB) was identified to be an endogenous, peptide ligand for the orphan receptors GPR7 and GPR8. Because GPR7 is expressed in rat brain and, in particular, in the hypothalamus, we hypothesized that NPB might interact with neuroendocrine systems that control hormone release from the anterior pituitary gland. No significant effects of NPB were(More)
Neuropeptide W (NPW) is produced in neurons located in hypothalamus and brain stem, and its receptors are present in the hypothalamus, in particular in the paraventricular nucleus (PVN). Intracerebroventricular (ICV) administration of NPW activated, in a dose-related fashion, the hypothalamic-pituitary-adrenal axis, as determined by plasma corticosterone(More)
1. Cross-correlation analysis was performed on the discharges of motor units recorded from the same or from different finger muscles during weak, voluntary isometric contractions in man. 2. In 88% of cases such cross-correlograms contained a narrow central peak indicating synchronization between the firing of the contributory motor units. Expressed in terms(More)
A rhythmic modulation of motor unit discharge at 17-24 Hz has been observed in the tibialis anterior muscle of subjects who display a high degree of short-term synchrony. Motor unit discharges were recorded both from extensor digitorum communis in the arm and tibialis anterior in the leg during voluntary isometric contractions. Time domain analysis of motor(More)
The RF-amide peptides (RFRPs), including prolactin (PRL)-releasing peptide-31 (PrRP-31) and RFRP-1, have been reported to stimulate stress hormone secretion by either direct pituitary or indirect hypothalamic actions. We examined the possible direct effects of these peptides on PRL and adrenocorticotropin (adrenocorticotropic hormone [ACTH]) release from(More)
Physiologic control of prolactin (PRL) secretion is largely dependent upon levels of dopamine accessing the adenohypophysis via the hypophysial portal vessels. However, it is clear that other factors of hypothalamic origin can modulate hormone secretion in the absence or presence of dopamine. Several neuropeptides have been identified as PRL releasing(More)
Short-term synchrony between the discharges of motor units has been assessed in Parkinson's disease (PD) and normal man. The discharges of single motor units were recorded in the extensor digitorum communis (EDC) muscle of the forearm or the tibialis anterior (TA) muscle of the leg during weak, voluntary isometric contraction. Short-term synchrony was(More)
Residual dipolar couplings (RDCs) have been observed in disordered states of several proteins. While their nonuniform values were initially surprising, it has been shown that reasonable approximation of experimental RDCs can be obtained using simple statistical coil models and assuming global alignment of each structure, provided that many thousands of(More)