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STUDY DESIGN Retrospective case series. OBJECTIVE The purpose of this study was to report on a large consecutive series of posterolateral fusion cases using rhBMP-2/ACS. SUMMARY OF BACKGROUND DATA Despite evidence that rhBMP-2/ACS is effective as an iliac crest graft substitute in posterolateral fusion, concerns remain regarding potential risk for BMP(More)
Bone morphogenetic protein (BMP) is commonly used as an ICBG substitute for transforaminal lumbar interbody spine fusion (TLIF). However, multiple recent reports have raised concerns regarding a substantial incidence of perioperative radiculopathy. Also, given the serious complications reported with anterior cervical BMP use, risks related to swelling and(More)
BACKGROUND CONTEXT Although numerous studies have been published, controversy still exists regarding fusion and nonsurgical treatment for symptomatic degenerative lumbar spine conditions. Definite conclusions are difficult to draw because of differences in patient inclusion criteria, fusion technique, nonoperative treatment regimen, and clinical outcome(More)
BACKGROUND CONTEXT Considerable debate exists regarding the incidence of persistent pain from the iliac crest bone graft (ICBG) harvest site. Different study designs have led to a variety of reported rates. PURPOSE The purpose of this study was to determine the incidence and severity of bone graft site pain after iliac crest harvest. STUDY DESIGN(More)
OBJECTIVE Autism occurs more frequently in individuals with Down syndrome than it does in the general population. Among children with autism and Down syndrome, regression is reported to occur in up to 50%. The aim of this study was to characterize and compare regression in children with autism with and without Down syndrome. METHODS In this case-control(More)
STUDY DESIGN Literature-based topic review. OBJECTIVE To review the complications and the concerns that may be associated with all of the commonly used osteobiologic options for spine fusion. SUMMARY OF BACKGROUND DATA Obtaining a solid arthrodesis is an important objective in many lumbar surgical procedures, and a wide array of bone graft materials may(More)
A major sequelae of lumbar fusion is acceleration of adjacent-level degeneration due to decreased lumbar lordosis. We evaluated the effectiveness of 4 common fusion techniques in restoring lordosis: instrumented posterolateral fusion, translumbar interbody fusion, anteroposterior fusion with posterior instrumentation, and anterior interbody fusion with(More)
We report the surgical treatment results for 7 patients (4 men, 3 women; mean age, 49 years) who presented with myelopathy caused exclusively by primary thoracic spinal stenosis, predominantly in the lower thoracic spine. (Patients with concurrent ascending lumbosacral degenerative disease were excluded.) All patients received extensive nonoperative(More)
STUDY DESIGN Retrospective cohort analysis. OBJECTIVE To investigate health-related quality of life improvements in patients undergoing lumbar fusion to revise a previous lumbar spine surgery. SUMMARY OF BACKGROUND DATA Spinal fusion is often used as a surgical intervention in patients who have previously undergone lumbar surgery. Prior studies suggest(More)
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