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The chemokine stromal cell-derived factor (SDF-1; also known as chemokine ligand 12 [CXCL12]) regulates many essential biological processes, including cardiac and neuronal development, stem cell motility, neovascularization, angiogenesis, apoptosis, and tumorigenesis. It is generally believed that SDF-1 mediates these many disparate processes via a single(More)
Responses of Antarctic pack-ice seals to environmental change and increasing krill fishing" (2012). Keywords: Antarctic pack-ice seals Climate change Fisheries management Habitat change Krill Uncertainty a b s t r a c t The compound effects of changing habitats, ecosystem interactions, and fishing practices have implications for the management of Antarctic(More)
OBJECTIVE Posttraumatic stress disorder symptoms are a focus of much research with older children, but little research has been conducted with young children, who account for about 50% of all pediatric burn injuries. This is a 3-year study of 12- to 48-month-old acutely burned children to assess acute traumatic stress outcomes. The aims were to (1) assess(More)
  • Thomas Piketty, Thomas Bender, Daniel Woolf, David Christian, Ulinka Rublack, Georg G Iggers +25 others
  • 2014
How should historians speak truth to power – and why does it matter? Why is five hundred years better than five months or five years as a planning horizon? And why is history – especially long-term history – so essential to understanding the multiple pasts which gave rise to our conflicted present? The History Manifesto is a call to arms to historians and(More)
Extended breath-hold endurance enables the exploitation of the aquatic niche by numerous mammalian lineages and is accomplished by elevated body oxygen stores and adaptations that promote their economical use. However, little is known regarding the molecular and evolutionary underpinnings of the high muscle myoglobin concentration phenotype of divers. We(More)
Northern fur seal (Callorhinus ursinus; NFS) populations have been declining, perhaps due to limited foraging ability of pups. Because a marine mammal’s proficiency at exploiting underwater prey resources is based on the ability to store large amounts of oxygen (O2) and to utilize these reserves efficiently, this study was designed to determine if NFS pups(More)
The beta-chemokine RANTES (regulated on activation, normal T cell expressed and secreted) suppresses the infection of susceptible host cells by macrophage tropic strains of HIV-1. This effect is attributed to interactions of this chemokine with a 7-transmembrane domain receptor, CCR5, that is required for virus-cell fusion and entry. Here we identify(More)
OBJECTIVE Symptoms of posttraumatic stress disorder (PTSD) are a focus of much research with older children, but little research has been conducted with young children, who account for about 40% of all pediatric burn injuries. This is a longitudinal study of 72 acutely burned children (12-48 months old) that assessed the course of acute posttraumatic(More)
With her flowing cape, ivory cigarette holder, dollar-sign pin and a pen name lifted from a typewriter, Ayn Rand was a tempting target for satirists. Her novels, according to an army of critics, were horrendously written-and could not be taken seriously as political philosophy. And yet, 20 years after her death, she remains an icon in libertarian and(More)
Mass and body composition are indices of overall animal health and energetic balance and are often used as indicators of resource availability in the environment. This study used morphometric models and isotopic dilution techniques, two commonly used methods in the marine mammal field, to assess body composition of Weddell seals (Leptonychotes weddellii, N(More)