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CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices
TLDR
Evidence for a dynamic complex with NBD1 that transiently engages different sites of the R region suggests a structural explanation for the dependence of CFTR activity on multiple PKA phosphorylation sites.
Congenital Chloride-losing Diarrhea Causing Mutations in the STAS Domain Result in Misfolding and Mistrafficking of SLC26A3*
TLDR
The data suggest that these CLD-causing mutations cause disease by at least two distinct molecular mechanisms, both ultimately leading to loss of functional protein at the plasma membrane.
Calculation of residual dipolar couplings from disordered state ensembles using local alignment.
TLDR
By using short local alignment tensors, good agreement is achieved between experimental and simulated RDCs with far fewer structures than required when using global alignment, making the possibility of using R DCs as direct restraints in structural calculations of disordered proteins much more feasible.
Analysis of the Complete Genome of the Alkaliphilic and Phototrophic Firmicute Heliorestis convoluta Strain HHT
TLDR
An analysis of the complete genome of a second heliobacterium, Heliorestis (Hrs.) convoluta str.
Knoevenagel condensation catalyzed by K2NiP2O7. Synthesis of (E)-methyl-α-cyanocinnamates in high yields
The Knoevenagel reaction of benzaldehyde and several chloroderivatives with methyl cyanoacetate catalyzed by K2NiP2O7 leads to methyl (E)-α-cyanocinnamate derivatives in 40 min with yields of
Slow and steady wins the race: an examination of bacterial persistence
TLDR
An overview of the major features of bacterial persistence, including the various conditions that precipitate persister formation, are provided and a discussion of several of the better-characterized molecular mechanisms that trigger this distinctive mode of bacterial dormancy are provided.
Genome Sequence of Rhodoferax antarcticus ANT.BRT; A Psychrophilic Purple Nonsulfur Bacterium from an Antarctic Microbial Mat
TLDR
This report represents the first genomic analysis of a psychrophilic anoxygenic phototroph and provides a glimpse of the genetic basis for maintaining a phototrophic lifestyle in a permanently cold, yet highly variable, environment.
Chemoorganotrophic Bacteria From Lake Fryxell, Antarctica, Including Pseudomonas Strain LFY10, a Cold-Adapted, Halotolerant Bacterium Useful in Teaching Labs
TLDR
These cold-adapted bacteria likely play a role in carbon mineralization and other nutrient cycling in Lake Fryxell, and their characterization broadens the understanding of microbial biodiversity in aquatic polar ecosystems.
Structural Characterization and Interactions of the CFTR Regulatory Region
The intrinsically disordered nonphosphorylated and phosphorylated R region of CFTR and its interactions with NBD1 and SLC26A3 STAS have been characterized at residuespecific resolution, primarily
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