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Collagen I matrix turnover is regulated by fibronectin polymerization.
Extracellular matrix (ECM) remodeling occurs during normal homeostasis and also plays an important role during development, tissue repair, and in various disease processes. ECM remodeling involvesExpand
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Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels
Vascular smooth muscle cells (VSMCs) show pronounced heterogeneity across and within vascular beds, with direct implications for their function in injury response and atherosclerosis. Here we combineExpand
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The role of smooth muscle cells in plaque stability: Therapeutic targeting potential
Events responsible for cardiovascular mortality and morbidity are predominantly caused by rupture of “vulnerable” atherosclerotic lesions. Vascular smooth muscle cells (VSMCs) play a key role inExpand
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Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation
Jmjd2 H3K9 demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity. However, little is known about their importance at the exit of ESC pluripotency. Here, we reveal that Jmjd2cExpand
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Epigenetic Regulation of Vascular Smooth Muscle Cells by Histone H3 Lysine 9 Dimethylation Attenuates Target Gene-Induction by Inflammatory Signaling
Supplemental Digital Content is available in the text.
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Jmjd 2 c / Kdm 4 c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation
Jmjd2/Kdm4 H3K9-demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity. However, little is known about their importance at the exit of ESC pluripotency. Here, we uncover thatExpand
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Primed smooth muscle cells acting as first responder cells in disease
Rationale Vascular smooth muscle cell (VSMC) dysregulation is a hallmark of vascular disease, including atherosclerosis. In particular, the majority of cells within atherosclerotic lesions areExpand