Jennifer King Chen

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OBJECTIVE Loeys-Dietz syndrome is a newly described phenotype caused by heterozygous mutations in the genes encoding type I or II transforming growth factor-beta (TGF-beta) receptor. Characterized by a unique constellation of clinical and pathologic findings, Loeys-Dietz syndrome manifests with aggressive vascular pathology. Aneurysms may form at a young(More)
Port wine stains (PWS) are the most common vascular malformation of the skin, occurring in 0.3% to 0.5% of the population. Noninvasive laser irradiation with flashlamp-pumped pulsed dye lasers (selective photothermolysis) currently comprises the gold standard treatment of PWS; however, the majority of PWS fail to clear completely after selective(More)
PURPOSE Treatment of glioblastoma (GBM) is limited by therapeutic ratio; therefore, successful therapy must be specifically cytotoxic to cancer cells. Hypoxic cells are ubiquitous in GBM, and resistant to radiation and chemotherapy, and, thus, are logical targets for gene therapy. In this study, we investigated whether cytosine deaminase(More)
RATIONALE AND OBJECTIVES To compare the utility of a search engine, Google, with other medical and non-medical, web-based resources for identifying specific medical information. MATERIALS AND METHODS This institutional review board-approved case cross-over study randomly assigned 89 medical student volunteers to use either Google or any other web-based(More)
AIM To determine the incidence of endophthalmitis following 25-gauge and standard 20-gauge vitrectomy. METHODS In this single-centre retrospective interventional case series, we evaluated the incidence of acute endophthalmitis occurring within the 14-day postoperative period in all patients who underwent pars plana vitrectomy between 1 November 2002 and(More)
Nutritionally variant streptococci (NVS) are an unusual but significant cause of endocarditis, with increased morbidity and mortality compared to those caused by enterococci or viridans streptococci. For many reasons, NVS endocarditis has remained very difficult to treat medically with antibiotics, and when the bacteria infect prosthetic valves, surgical(More)
Three studies examined the self-affirmational role of relational selves, or aspects of the self in relation to significant others. The overriding hypothesis was that individuals who view relational selfaspects as core to their identity are particularly likely to use them as self-affirmational resources in the face of threat. Supporting this, threat was(More)
OBJECTIVE Traumatic arteriovenous (AV) fistulas present with a variety of clinical manifestations and may prove difficult to detect. The clinical sequelae of undiagnosed AV fistulas are significant and include dilatation of the vessels, venolymphatic trophic complications, and heart failure. In this article, we report two rare cases involving long-standing(More)
One major challenge in treating glioblastoma multiforme (GBM) has been the presence of radiation-resistant hypoxic cells. The pro-apoptosis protein BAX has been reported to be a possible radiation sensitizer of cancer cells; however, to our knowledge, no studies have reported on the effects of BAX on radiation sensitivity under hypoxic conditions.(More)