Learn More
Platelet concentrates stored for up to 5 days at room temperature or irradiated with 15 Gy immediately prior to transfusion were evaluated for their ability to increase the platelet count in thrombocytopenic patients. Platelets irradiated with a dose of 15 Gy immediately prior to transfusion achieved corrected increments (CI) at 1 and 20 h after transfusion(More)
AIMS To study the distribution of clinically important red cell antibodies in pregnancy, and the associated fetal and neonatal morbidity and mortality. METHODS The case notes of women with clinically important red cell antibodies identified in their serum during pregnancy were reviewed. RESULTS During a 12 month period 22,264 women were referred for(More)
BACKGROUND In February 2004, FDA approved a supplement to our biologics license for Carticel, autologous cultured chondrocytes, to use the BacT/ALERT microbial detection system as an alternative to the compendial sterility test for lot release. This article provides a roadmap to our approval process. The approval represents more than 4 years of development(More)
Chronic myelomonocytic leukaemia (CMML) is typically associated with a prolonged clinical course and is not usually very responsive to chemotherapeutic intervention. Skin infiltration has not been recognized previously as a feature of this illness. We have seen four patients recently with CMML, who during the the course of their illness developed marked(More)
In doing so it acknowledges changes in transfusion practice during the past decade, particularly in respect of safety issues and further published transfusion-related guidelines. The transfusion requirements of the neonate are recognized as unique, but there are other groups of children who are regularly transfused and who have very specific transfusion(More)
We have encountered an allele which seems to be another type of O allele at the human histo-blood group ABO locus. We have determined the nucleotide sequence of this allele over the coding region in the last two coding exons. This allele does not possess the single-nucleotide deletion found common among all the O alleles previously analyzed. Compared with(More)
Plasma prothrombin fragment F 1 + 2 (F1 + 2), thrombin-antithrombin complexes (TAT), fibrinogen and factor VII were related to variables associated with increased cardiovascular risk in 86 plasma donors (49 male and 37 female). F1 + 2 had a log-normal distribution and increased significantly with age and body mass index (BMI). Significantly, higher F1 + 2(More)
A dispermic human chimaera is described who is a fertile female XX/XY chimaera. The chimaera was discovered due to anomalies found during routine antenatal testing. The patient had two red cell populations differing in three blood group systems; ABO, Rh and MN. Analysis of cultured lymphocytes showed 70% of cells to have the 46, XY male karyotype and(More)
In the UK a Kleihauer test is routinely performed on all RhD-negative women after the birth of an RhD-positive child to ensure that an adequate dose of anti-D immunoglobulin is given. The results of Kleihauer testing are interpreted to assess the volume of any feto-maternal haemorrhage and additional anti-D immunoglobulin is administered if necessary. A(More)