Jennifer J. Haas

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The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the roles of each pattern recognition receptor in rhinovirus infection using primary bronchial epithelial cells. TLR3 was constitutively expressed; however, RIG-I and MDA5 were inducible by 8-12 h following(More)
The importance of NF-kB activation and deficient anti-viral interferon induction in the pathogenesis of rhinovirus-induced asthma exacerbations is poorly understood. We provide the first in vivo evidence in man and mouse that rhinovirus infection enhanced bronchial epithelial cell NF-kB p65 nuclear expression, NF-kB p65 DNA binding in lung tissue and(More)
Please do not quote or cite without permission from authors. and two anonymous reviewers for helpful discussions and comments on earlier drafts; they are not responsible for errors that may remain. They also thank Eric Gerstenberger for excellent computer programming assistance and the AHRQ Data Center for their assistance with using the MEPS data. Abstract(More)
Patient participation in cancer clinical trials is imperative to the advancement of medical science. Physicians play an important role in recruitment by discussing clinical trials with their cancer patients. Patient–physician discussion is influenced by many factors relating to the physician, the patient, and the healthcare system. Physicians selected from(More)
The importance of NF-κB activation and deficient anti-viral interferon induction in the pathogenesis of rhinovirus-induced asthma exacerbations is poorly understood. We provide the first in vivo evidence in man and mouse that rhinovirus infection enhanced bronchial epithelial cell NF-κB p65 nuclear expression, NF-κB p65 DNA binding in lung tissue and(More)
Defective Rhinovirus induced interferon-β and interferon-λ production has been reported in bronchial epithelial cells from asthmatics but the mechanisms of defective interferon induction in asthma are unknown. Virus infection can induce interferon through Toll like Receptors (TLR)3, TLR7 and TLR8. The role of these TLRs in interferon induction in asthma is(More)
In complex survey sampling, a fraction of a finite population is sampled. Often, the survey is conducted so that each subject in the population has a different probability of being selected into the sample. Further, many complex surveys involve stratification and clustering. For generalizability of the sample to the finite population, these features of the(More)
OBJECTIVE Seasonal influenza occurs in annual epidemics. The virus can cause severe illness and concomitant diseases with the highest risk for children, the elderly, and individuals with disease dispositions. The study objective is to assess the influenza burden in Germany. METHODS This retrospective claims data analysis used the Health Risk Institute(More)