Jennifer H-C Shen

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Genetic studies in mice suggest that Wnt4 signaling antagonizes expression of male hormones and effectively blocks male development in the female embryo. We recently identified an XY intersex patient carrying a chromosomal duplication of the WNT4 locus and proposed that this patient's feminization arises from an increased dosage of WNT4. To test this(More)
Steroidogenic factor 1 (SF-1) is an essential factor in endocrine proliferation and gene expression. Despite the fact that SF-1 expression is restricted to specialized cells within the endocrine system, the only identified regulatory factors of SF-1 are the ubiquitously expressed E-box proteins (upstream stimulatory factors 1 and 2). Sequence examination of(More)
As IC chips get faster and smaller, the synchronous design method has hit upon the limitations of clock skew, higher power dissipation, and timing verifications. Now asynchronous design is being used to overcome those boundaries. It relies on request / acknowledge signalling instead of clock driven operation. This project will implement an asynchronous(More)
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