Jennifer Gunning

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Nerve growth factor (NGF) is a member of an expanding family of neurotrophic factors (including brain-derived neurotrophic factor and the neurotrophins) that control the development and survival of certain neuronal populations both in the peripheral and in the central nervous systems. Its biological effects are mediated by a high-affinity ligand-receptor(More)
The first successful cord cell transplant to a sibling with Fanconi's anaemia took place 15 years ago. This proven utility of cord blood led to the establishment of cord blood banks both private and public and there are now nearly 100 cord blood banks worldwide. It is estimated that over 200,000 cord blood units (CBU) are held by the private sector and over(More)
60 hospitalized patients with pelvic inflammatory disease entered a randomised study to compare the therapeutic efficacy and tolerability of parenteral sulbactam/ampicillin with that of clindamycin/gentamicin. All 49 pathogens isolated at entry from 21 evaluable patients in the sulbactam/ampicillin group were eradicated. 34 out of 35 pathogens isolated from(More)
Relatively few countries have legislation addressing oocyte donation. Where such legislation does exist it is entirely in the context of broader legislation concerned with the regulation of in-vitro fertilization (IVF) or assisted reproduction more generally. Within Western Europe only nine countries so far have passed Acts addressing assisted reproduction.(More)
The syntheses of 1,2-dideoxy-D-ribofuranose and 1,2-dideoxy-1-phenyl-beta-D-ribofuranose are described. Oligodeoxynucleotides containing these analogues have been synthesised and hybridized to their complementary strands. Hypochromicity studies have shown that these duplices are less stable than either the totally complementary duplex or those containing(More)
The secondary structure of crystalline nerve growth factor (NGF) has been measured with 90% confidence to contain between 0 and 11% helix and between 53 and 67% antiparallel beta-strand using the intensity distribution of the amide I region of the Raman spectrum. A comparison of spectra collected from crystals and solutions confirms that the secondary(More)
Stem cells from umbilical cord blood probably now form one of the most commonly banked types of human tissue. Originally stored for the treatment of haematological disorders these stem cells have now been found to be more versatile, even pluripotent, with potential for use in the treatment of a broader range of disorders and diseases and may be particularly(More)
Legislation in the area of assisted reproduction has been a slow process and one dogged by conflicting ethical views. Where legislation has been introduced in Europe it has not been consistent, representing the different cultural environments of the countries concerned and in a number of countries legislation has still not been introduced. Although the 1997(More)