Jennifer Chandler

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Extracellular matrix remodeling occurs during development, tissue repair, and in a number of pathologies, including fibrotic disorders, hypertension, and atherosclerosis. Extracellular matrix remodeling involves the complex interplay between extracellular matrix synthesis, deposition, and degradation. Factors that control these processes are likely to play(More)
Communication between cells and the extracellular matrix (ECM) is critical for regulation of cell growth, survival, migration, and differentiation. Remodeling of the ECM can occur under normal physiological conditions, as a result of tissue injury, and in certain pathological conditions. ECM remodeling leads to alterations in ECM composition and(More)
* Assistant Professor of Law, University of Ottawa. The author thanks the Centre for Innovation Law and Policy for financial support for the writing of this article. The author also thanks Paul Zatychec and Dean Bruce Feldthusen (of the University of Ottawa Faculty of Law) for most valuable discussions and suggestions, as well as Dina Mashayekhi and William(More)
Deubiquitinating enzymes are essential to the ubiquitin (Ub)/26S proteasome system where they release Ub monomers from the primary translation products of poly-Ub and Ub extension genes, recycle Ubs from polyubiquitinated proteins, and reverse the effects of ubiquitination by releasing bound Ubs from individual targets. The Ub-specific proteases (UBPs) are(More)
Particle tracing in time-varying flow fields is traditionally performed by numerical integration of the underlying vector field. This procedure can become computationally expensive, especially in scattered, particle-based flow fields, which complicate interpolation due to the lack of an explicit neighborhood structure. If such a particle-based flow field(More)
This article addresses the question of how neuroscientific evidence is currently used in the Canadian criminal justice system, with a view to identifying the main contexts in which this evidence is raised, as well as to discern the impact of this evidence on judgements of responsibility, dangerousness, and treatability. The most general Canadian legal(More)
A priority system is one in which previously registered donors receive a preference in the allocation of organs for transplant ahead of those who have not registered. Supporters justify these systems on the basis that they are fair and will encourage donor registration. This article reviews existing studies of public reactions to priority systems, as well(More)
Organ transplantation has been described “with only slight exaggeration [as] usher[ing] in the age of bioethics” as it has focused public attention on the practice and its associated ethical issues. These compelling ethical issues have inspired a voluminous body of writing in the medical, legal and philosophical literature. These authors debate the(More)