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Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same pathways might be offset by increased cancer risk on account of their propensity to boost cell survival. The Sir2/SIRT1 family of(More)
The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology.org, provides a structured, comprehensive and well-defined set of 10,088 classes (terms) describing human phenotypic abnormalities and 13,326 subclass relations between the HPO classes. In addition we have developed logical definitions for 46% of all HPO classes(More)
1. PROPOSAL Students in science and engineering are poorly served by most general-purpose CS-1 courses, which rarely discuss scientific problems or applications. At the same time, fewer and fewer computer science students are exposed to scientific ideas or thinking in any of their introductory courses. This divide hurts both sides: scientists and engineers(More)
BACKGROUND Traditionally, non-small cell lung cancer is treated as a single disease entity in terms of systemic therapy. Emerging evidence suggests the major subtypes--adenocarcinoma (AC) and squamous cell carcinoma (SqCC)--respond differently to therapy. Identification of the molecular differences between these tumor types will have a significant impact in(More)
We compare a traditional CS1 offering with an inverted offering delivered the following year to a comparable student population. We measure student attitudes, grades, and final course outcomes and find that, while students in the inverted offering do not report increased enjoyment and are no more likely to pass, learning as measured by final exam(More)
Overgrowth syndromes comprise a group of heterogeneous disorders characterised by excessive growth parameters, often in association with intellectual disability. To identify new causes of human overgrowth, we have been undertaking trio-based exome sequencing studies in overgrowth patients and their unaffected parents. Prioritisation of functionally relevant(More)
We investigated the effect of lexical stress on 16-month-olds' ability to form associations between labels and paths of motion. Disyllabic English nouns tend to have a strong-weak (trochaic) stress pattern, and verbs tend to have a weak-strong (iambic) pattern. We explored whether infants would use word stress information to guide word-action associations(More)
Mass spectrometry has become the technology of choice for detailed identification of proteins in complex mixtures. Although electrophoretic separation, proteolytic digestion, mass spectrometric analysis of unseparated digests, and database searching have become standard methods in widespread use, peptide sequence information obtained by collision-induced(More)