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The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology.org, provides a structured, comprehensive and well-defined set of 10,088 classes (terms) describing human phenotypic abnormalities and 13,326 subclass relations between the HPO classes. In addition we have developed logical definitions for 46% of all HPO classes(More)
1. PROPOSAL Students in science and engineering are poorly served by most general-purpose CS-1 courses, which rarely discuss scientific problems or applications. At the same time, fewer and fewer computer science students are exposed to scientific ideas or thinking in any of their introductory courses. This divide hurts both sides: scientists and engineers(More)
The present study is the first behavioral genetic investigation of relationships between the Dark Triad of personality--Machiavellianism, narcissism, and subclinical psychopathy--and moral development. Participants were 154 monozygotic twin pairs and 82 same-sex dizygotic twin pairs. Higher scores on Machiavellianism and psychopathy were positively(More)
Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same pathways might be offset by increased cancer risk on account of their propensity to boost cell survival. The Sir2/SIRT1 family of(More)
BACKGROUND Traditionally, non-small cell lung cancer is treated as a single disease entity in terms of systemic therapy. Emerging evidence suggests the major subtypes--adenocarcinoma (AC) and squamous cell carcinoma (SqCC)--respond differently to therapy. Identification of the molecular differences between these tumor types will have a significant impact in(More)
We compare a traditional CS1 offering with an inverted offering delivered the following year to a comparable student population. We measure student attitudes, grades, and final course outcomes and find that, while students in the inverted offering do not report increased enjoyment and are no more likely to pass, learning as measured by final exam(More)
BACKGROUND More than half of the approximately 500,000 women diagnosed with cervical cancer worldwide each year will die from this disease. Investigation of genes expressed in precancer lesions compared to those expressed in normal cervical epithelium will yield insight into the early stages of disease. As such, establishing a baseline from which to compare(More)
  • Eva-Maria Ratai, Jeffrey P. Bombardier, Chan-Gyu Joo, Lakshmanan Annamalai, Tricia H. Burdo, Jennifer Campbell +10 others
  • 2010
BACKGROUND Despite the advent of highly active anti-retroviral therapy (HAART), HIV-associated neurocognitive disorders continue to be a significant problem. In efforts to understand and alleviate neurocognitive deficits associated with HIV, we used an accelerated simian immunodeficiency virus (SIV) macaque model of NeuroAIDS to test whether minocycline is(More)