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BACKGROUND Roughly a third of patients with rheumatoid arthritis treated with biological treatments receive them as monotherapy. Tocilizumab--an inhibitor of interleukin 6 receptor signalling--has been studied as monotherapy in several clinical trials. We assessed the efficacy and safety of tocilizumab monotherapy compared with adalimumab monotherapy for(More)
BACKGROUND Little is known about patient perspectives of the transition from hospital to home. OBJECTIVE To develop a richly detailed, patient-centered view of patient and caregiver needs in the hospital-to-home transition. DESIGN An ethnographic approach including participant observation and in-depth, semi-structured video recorded interviews. (More)
A new formulation of zolmitriptan has been developed that dissolves on the tongue without the need for additional fluid intake. In this double-blind, parallel study, 471 patients were randomized to receive the zolmitriptan orally disintegrating tablet 2.5 mg (n=231) or matching placebo (n=240) to treat a single moderate or severe migraine. Headache relief(More)
OBJECTIVE To determine the efficacy and safety of ocrelizumab (OCR) with methotrexate (MTX) in MTX-naive rheumatoid arthritis (RA) patients. METHODS In a randomised, double-blind, controlled trial, patients received placebo+MTX (MTX; n=210), OCR 200 mg×2+MTX (OCR 200; n=200) or OCR 500 mg×2+MTX (OCR 500; n=203). OCR/placebo (two intravenous infusions) was(More)
Detailed chemical, spectroelectrochemical and computational studies have been used to investigate the mechanism of hypoxia selectivity of a range of copper radiopharmaceuticals. A revised mechanism involving a delicate balance between cellular uptake, intracellular reduction, reoxidation, protonation and ligand dissociation is proposed. This mechanism(More)
Automatic programming is the use of search techniques to find programs that solve a problem. The most commonly explored automatic programming technique is genetic programming, which uses genetic algorithms to carry out the search. In this paper we introduce a new technique called Ant Colony Programming (ACP) which uses an ant colony based search in place of(More)
Two new types of unsymmetrical bis(thiosemicarbazone) proligands and their neutral zinc(II) and copper(II) complexes have been synthesized. These bifunctional ligands both chelate the metal ions and provide pendent amino groups that can be readily functionalized with biologically active molecules. Functionalization has been demonstrated by the synthesis of(More)
Ethnic politics and political corruption are important concerns in many developing country democracies. We conducted field experiments in rural India to examine the responsiveness of voter preferences to priming about the relevance of ethnicity and politician quality for service delivery. We used vignette experiments to examine how voter preferences vary(More)
Despite the long history of the Fischer-Tropsch reaction, carbon monoxide has proven remarkably resistant to selective homologation under mild conditions. Here, we find that an organouranium(III) complex induces efficient reductive trimerization of carbon monoxide at room temperature and pressure. The result is a triangular, cyclic C3O(2-)3, or deltate,(More)
OBJECTIVE Between January and September 2006, the authors examined when, why, if, and how nutrition labels impact food purchase decisions of college students. PARTICIPANTS Participants were 16 college-aged students at a large northeastern university. METHODS As part of a larger study undertaken at a large northeastern university on the effect of(More)