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The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity.
Synthesis and Olfactory Characterization of Novel Silicon‐Containing Acyclic Dienone Musk Odorants
With an odor threshold value of 0.54 ng L–1 air, (3E,5E)-7,7-dimethyl-5-tert-butylocta-3,5-dien-2-one (1a) constitutes the most potent member of a new family of acyclic musk odorants with ionone…
Novel Silicon‐Containing Analogues of the Retinoid Agonist Bexarotene: Syntheses and Biological Effects on Human Pluripotent Stem Cells
Preliminary evidence indicates that disila‐bexarotene and its analogues 8 and 9 may possess enhanced functions over the parent compound bexarotenes, such as induction and regulation of cell death and cell numbers.
Disila-galaxolide and derivatives: synthesis and olfactory characterization of silicon-containing derivatives of the musk odorant galaxolide.
The introduction of a 7-methylene group in disila-galaxolide (4 b→rac-9) improved the odor threshold by a factor of two and the presumed hydrophobic bulk binding pocket of the corresponding musk receptor(s) could be characterized in more detail, which could be useful for the design of novel musk odorants with an improved environmental profile.