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ii I certify that I have read this dissertation and that in my opinion it is fully adequate, in scope and in quality, as a dissertation for the degree of Doctor of Philosophy. I certify that I have read this dissertation and that in my opinion it is fully adequate, in scope and in quality, as a dissertation for the degree of Doctor of Philosophy. I certify(More)
Precise estimations of molecular rates are fundamental to our understanding of the processes of evolution. In principle, mutation and evolutionary rates for neutral regions of the same species are expected to be equal. However, a number of recent studies have shown that mutation rates estimated from pedigree material are much faster than evolutionary rates(More)
Type-1 fimbriae are important virulence factors for the establishment of Escherichia coli urinary tract infections. Bacterial adhesion to the high-mannosylated uroplakin Ia glycoprotein receptors of bladder epithelium is mediated by the FimH adhesin. Previous studies have attributed differences in mannose-sensitive adhesion phenotypes between faecal and(More)
is part of Compaq's Corporate Research group. Our focus is research on information technology that is relevant to the technical strategy of the Corporation and has the potential to open new business opportunities. Research at WRL ranges from Web search engines to tools to optimize binary codes, from hardware and software mechanisms to support scalable(More)
Performance is a central requirement to the wide-spread adoption of virtualization. To deliver on the promise of simplifying IT via virtualization, the virtualization platform must provide excellent performance with minimal effort. Virtualization performance encompasses several different dimensions. An application running in a virtual machine must perform(More)
BACKGROUND AND PURPOSE In an attempt to improve the gait of people with Parkinson disease (PD), researchers have examined the effect of visual cues placed on the floor. These studies typically have used a single session of training with such cues and have not examined the long-term carryover of such training. In the present study, therefore, gait was(More)
Opioid dependence is a problem of national concern, especially with dramatically increased rates of abuse and dependence of prescription opioids. The current article provides an up-to-date review of the literature on opioid dependence treatment, with a focus on conclusions drawn by experts in the field (e.g., Cochrane reviews and meta-analyses) and(More)
Environmental risk assessments (ERA) support regulatory decisions for the commercial cultivation of genetically modified (GM) crops. The ERA for terrestrial agroecosystems is well-developed, whereas guidance for ERA of GM crops in aquatic ecosystems is not as well-defined. The purpose of this document is to demonstrate how comprehensive problem formulation(More)
Although stereotypy is one of the key diagnostic features of autism, few studies have compared stereotypic behavior in children with autism and typically developing children. The present study employed direct observational measurement methods to assess levels of stereotypic behavior in 2-, 3- and 4-year-old children with autism or pervasive developmental(More)
This paper describes a highly structured assessment protocol with objective behavioral measures for joint attention responding and initiation. The assessment was given to 26 children diagnosed with autism spectrum disorders and 21 typically developing children, aged two to four years. Interobserver agreement was high for all behavioral measures. Children(More)