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  • Mark P Sabat, John C Vanrens, +10 authors Michael J. Janusz
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2006 (First Publication: 1 December 2006)
  • This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolarContinue Reading
  • Jennifer A. Maier, Todd A. Brugel, +9 authors Michael J. Janusz
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2006 (First Publication: 1 July 2006)
  • A new class of lymphocyte specific tyrosine kinase (lck) inhibitors based on an N-4,6-pyrimidine-N-alkyl-N'-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar inhibitionContinue Reading
  • Todd A. Brugel, Jennifer A. Maier, +10 authors Michael J. Janusz
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2006 (First Publication: 1 July 2006)
  • A new class of tumor necrosis factor alpha (TNF-alpha) synthesis inhibitors based on an N-2,4-pyrimidine-N-phenyl-N'-phenyl urea scaffold is described. Many of these compounds showed low-nanomolarContinue Reading
  • Jennifer A. Maier, Todd A. Brugel, +12 authors Michael J. Janusz
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2006 (First Publication: 1 July 2006)
  • A new class of tumor necrosis factor alpha (TNF-alpha) synthesis inhibitors based on a N-2,4-pyrimidine-N-phenyl-N'-alkyl urea scaffold is described. Many of these compounds showed low-nanomolarContinue Reading
  • Mark P Sabat, John C Vanrens, +10 authors Michael J. Janusz
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2006 (First Publication: 1 August 2006)
  • This communication details the synthesis, biological activity, and proposed binding mode of a novel class of tri-cyclic derivatives of 1,2-dihydro-pyrimido[4,5-c]pyridazines 1 and 2. The most potentContinue Reading
  • David A. Alcorta, Jennifer A. Maier, Brian D Harfe, Michael J. Kelley
  • Biology
  • 2013 (First Publication: 15 April 2013)
  • Introduction: Chordoma is a rare malignancy arising in the axial skeleton from notochord remnants. The T-box transcription factor, Brachyury (T), is associated with familial chordoma, is expressed inContinue Reading