Jennifer A. Adams

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Important Ca2+ signals in the cytosol and organelles are often extremely localized and hard to measure. To overcome this problem we have constructed new fluorescent indicators for Ca2+ that are genetically encoded without cofactors and are targetable to specific intracellular locations. We have dubbed these fluorescent indicators 'cameleons'. They consist(More)
Hemorrhagic stroke is a significant cause of morbidity and mortality in children, and is frequently associated with intracranial vascular malformations. One prevalent form of these vascular malformations, cerebral cavernous malformation, is characterized by thin-walled vascular cavities that hemorrhage and has been linked to loss-of-function mutations in(More)
We identify a new mechanism in supergravity theories which leads to successful inflation without any need for fine tuning. The simplest model yields a spectrum of density fluctuations tilted away from scale-invariance and negligible gravitational waves. We demonstrate that this is consistent with the observed large-scale structure for a cold dark matter(More)
We identify a new mechanism in supergravity theories which leads to successful inflation without any need for fine tuning. The simplest model yields a spectrum of density fluctuations tilted away from scale-invariance and negligible gravitational waves. We demonstrate that this is consistent with the observed large-scale structure for a cold dark matter(More)
The observed rate of change of the atmospheric carbon dioxide concentration at the South Pole, Fanning Island, Hawaii, and ocean weather station P correlates with an index of the southern oscillation and with El Niño occurrences. There are changes at all four stations that seem to be in response to the weak 1975 El Niño. Thus, even poorly developed El Niño(More)
Attempts at building an unified description of the strong, weak and electromagnetic interactions usually involve several stages of spontaneous symmetry breaking. We consider the effects of such symmetry breaking during an era of primordial inflation in supergravity models. In cases that these occur along flat directions at intermediate scales there will be(More)