Jenna L. Callender

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The larval salivary gland of Drosophila melanogaster synthesizes and secretes glue glycoproteins that cement developing animals to a solid surface during metamorphosis. The steroid hormone 20-hydroxyecdysone (20E) is an essential signaling molecule that modulates most of the physiological functions of the larval gland. At the end of larval development, it(More)
Ecdysteroid regulation of gene transcription in Drosophila melanogaster and other insects is mediated by a heterodimer comprised of Ultraspiracle (USP) and one of three ecdysone receptor (EcR) isoforms (A, B1 and B2). This study revealed that the EcR/USP heterodimer displays isoform-specific capabilities. EcRB1 is normally induced with a form of USP that is(More)
The functional insect ecdysteroid receptor is comprised of two nuclear receptors, the ecdysteroid receptor (EcR) and the RXR homologue, ultraspiracle (USP), which form a heterodimer. The dimer recognizes various hormone response elements and the effect of these elements on transcriptional activity of EcR isoforms was determined in vertebrate cells(More)
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