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The development of tolerance to the stimulatory action of caffeine upon mesencephalic reticular neurons and upon spontaneous locomotor activity was evaluated in rats after two weeks of chronic exposure to low doses of caffeine (5-10 mg/kg/day via their drinking water). These doses are achievable through dietary intake of caffeine-containing beverages in(More)
Carvedilol is a non-selective beta-adrenoreceptor antagonist that is also an antagonist at the alpha(1)-adrenoreceptor. This unique pharmacological effect may produce a different toxicodynamic profile compared to other beta-adrenoreceptor antagonists. Only one previous case of carvedilol overdose has been reported. Here, we report massive carvedilol(More)
The effects of caffeine and d-amphetamine sulfate were evaluated upon single unit activity of medial thalamus in chloral hydrate anesthetized rats. Single unit activity recorded extracellularly with platinum-iridium microelectrodes. It was found that caffeine, 0.1 to 0.5 mg/kg i.v., markedly suppressed and that amphetamine, 0.1 to 1 mg/kg i.v., markedly(More)
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