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Anti-proliferation effect of 3-amino-2-imino-3,4-dihydro-2H-1,3-benzothiazin-4-one (BJ-601) on human vascular endothelial cells: G0/G1 p21-associated cell cycle arrest.
TLDR
The data suggest that BJ-601 inhibits HDMVECs proliferation by increasing the level of p21 protein, which in turn inhibits CDK2 kinase activity, and finally causes retardation of the cell cycle at the G0/G1 phase. Expand
Melanogenesis Inhibitors from the Rhizoma of Ligusticum Sinense in B16-F10 Melanoma Cells In Vitro and Zebrafish In Vivo
TLDR
Findings suggest that (3S,3aR)-neocnidilide (8) is a potent antimelanogenic and non-cytotoxic natural compound and may be developed potentially as a skin-whitening agent for cosmetic uses. Expand
Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells.
TLDR
It is demonstrated that 2,3-epoxide substitution significantly potentiates the apoptotic effect of vitamin K3 via stimulating ROS production, which may be useful in the chemotherapy of glioblastoma cells. Expand
Anti-proliferation effect of 5,5-diphenyl-2-thiohydantoin (DPTH) in human vascular endothelial cells.
TLDR
It is demonstrated that DPTH at a range of concentrations dose- and time-dependently inhibited DNA synthesis and decreased cell number in cultured HUVEC, but not human fibroblasts, and might have the potential to inhibit the occurrence of angiogenesis. Expand
Structure and anti-proliferation function of 5,5-diphenyl-2-thiohydantoin (DPTH) derivatives in vascular endothelial cells.
TLDR
This work designed and synthesized several chemical compounds based on the structure-activity relationship consideration and showed that introduction of side chain containing an aromatic ring structure with right spatial arrangement at sulfur atom of DPTH enhanced the anti-angiogenic activity in HUVEC. Expand
5,5-Diphenyl-2-thiohydantoin-N10 (DPTH-N10) suppresses proliferation of cultured colon cancer cell line COLO-205 by inhibiting DNA synthesis and activating apoptosis
TLDR
The findings from the previous in vitro studies in DPTH-N10-induced anti-angiogenic effect and from the present in vitro Studies in DP TH-N 10-induced antiproliferation effect on colon cancer cell line strongly suggest the potential applications of DPTH -N10 in the treatment of human colon cancer. Expand
Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10).
TLDR
The data suggest that DPTH-N10 inhibits HUVEC proliferation by increasing the level of p21 protein, which in turn inhibits CDK2 kinase activity, and finally interrupts the cell cycle. Expand
Gallate-induced nanoparticle uptake by tumor cells: Structure-activity relationships.
TLDR
An analysis of the structure-activity relationship (SAR) revealed that the galloyl moiety exerted the most prominent enhancement effects on MNPcell which was further potentiated by the application of magnetic force. Expand
Tannins and Related Compounds from Quisqualis Indica
Continuous exploration of the chemical constituents of Combretaceous plants has led to the discovery of two novel ellagitannins, quisqualin A (1) and quisqualin B (2), from the fruits of QuisqualisExpand
Relative cardiotoxicity and cytotoxicity of anthraquinonyl glucosaminosides
TLDR
The adenocarcinomas were slightly more sensitive than the leukemias to the inhibitory action of the dihydroxylated anthraquinonyl glucosaminosides on cell growth, and cardiotoxicity was also increased in proportion to the number of hydroxyl groups present. Expand
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